G8044

Anti-phospho-GATA4 (pSer¹⁰⁵) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

• MDL號碼: MFCD06798487
• 分類程式碼代碼: 12352203
• NACRES: NA.41

屬性

• 生物源: rabbit
• 品質等級: 200
• 共軛: unconjugated
• 抗體表格: affinity isolated antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 形狀: buffered aqueous solution
• 分子量: antigen 46 kDa
• 物種活性: mouse
• 包裝: pkg of (1 vl = 100ul)
• 技術: western blot: 1:500
• UniProt登錄號: Q08369
• 運輸包裝: dry ice
• 儲存溫度: −70°C
• 基因資訊: human ... GATA4(2626) ; mouse ... Gata4(14463) ; rat ... Gata4(54254)

描述

免疫原

Anti-phospho-GATA4 (pSer¹⁰⁵) antibody produced in rabbit is suitable for western blotting at working dilution 1:500.

synthetic phosphopeptide derived from the region of GATA-4 that contains serine 105.

生化／生理作用

GATA-4 has a molar mass of 46kDa and belongs to the GATA family of zinc finger-containing transcription factors. It is involved in the development of cardiac hypertrophy and remodeling. It plays a crucial role in regulating basal and agonist or stress-induced gene expression in cardiac and smooth muscle cell types. Upon agonist stimulation via MEK1-ERK1/2, and weakly via JNK or p38 MAPKs, Ser¹⁰⁵ of GATA-4 is phosphorylated. Phosphorylation of GATA-4 by hepatocyte growth factor facilitates cell survival in cardiac muscle cells via MEK/ERK-dependent signaling pathway.

外觀

Solution in Dulbecco′s PBS, pH 7.3 with 1 mg/mL BSA and 0.05% Sodium Azide.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 10 - Combustible liquids