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Merck
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Key Documents

G6264

Sigma-Aldrich

鸟苷

BioReagent, suitable for cell culture

同義詞:

9-(β-D-呋喃核糖基)鸟嘌呤, 鸟嘌呤-9-β-D-呋喃核糖苷

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About This Item

經驗公式(希爾表示法):
C10H13N5O5
CAS號碼:
分子量::
283.24
Beilstein:
625911
EC號碼:
MDL號碼:
分類程式碼代碼:
12352205
PubChem物質ID:
NACRES:
NA.75

生物源

synthetic

品質等級

產品線

BioReagent

化驗

≥98%

形狀

powder

技術

cell culture | mammalian: suitable

mp

250 °C (dec.) (lit.)

溶解度

0.05 M acetic acid: 1 mg/mL, clear, colorless

運輸包裝

ambient

儲存溫度

room temp

SMILES 字串

[H]O[H].NC1=Nc2c(ncn2[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)C(=O)N1

InChI

1S/C10H13N5O5/c11-10-13-7-4(8(19)14-10)12-2-15(7)9-6(18)5(17)3(1-16)20-9/h2-3,5-6,9,16-18H,1H2,(H3,11,13,14,19)/t3-,5-,6-,9-/m1/s1

InChI 密鑰

NYHBQMYGNKIUIF-UUOKFMHZSA-N

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相關類別

應用

鸟苷已用作:
  • 作为基础培养基的核糖核苷组分,研究其对莫哈韦芽胞杆菌厌氧生长的影响
  • 作为杜氏改良Eagle培养基(DMEM)的组分,用于培养小鼠来源的胚胎干细胞
  • 作为核苷溶液的组分,用于培养鸡胚胎干细胞

生化/生理作用

鸟苷是一种在细胞代谢中起重要作用的嘌呤核苷。通过诱导增殖分化和抗凋亡作用,它在神经胶质细胞、海马神经元、嗜铬细胞瘤细胞中也表现出神经保护和神经营养作用。鸟苷可作为药物治疗多种神经疾病。它对败血症诱导的认知障碍、肝性脑病、脂多糖(LPS)诱导的炎症、缺血性损伤和叠氮化物诱导的氧化损伤有效果。鸟苷适用于细胞培养应用,作为一磷酸鸟苷(GMP)、二磷酸鸟苷(GDP)、三磷酸鸟苷(GTP)和环GMP(cGMP)的前体。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 2

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges


分析證明 (COA)

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Nadine Gehrke et al.
Immunity, 39(3), 482-495 (2013-09-03)
Immune sensing of DNA is critical for antiviral immunity but can also trigger autoimmune diseases such as lupus erythematosus (LE). Here we have provided evidence for the involvement of a damage-associated DNA modification in the detection of cytosolic DNA. The oxidized base
Jérémie Piton et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(22), 8858-8863 (2013-04-24)
The initiation of mRNA degradation often requires deprotection of its 5' end. In eukaryotes, the 5'-methylguanosine (cap) structure is principally removed by the Nudix family decapping enzyme Dcp2, yielding a 5'-monophosphorylated RNA that is a substrate for 5' exoribonucleases. In
Zoran D Matović et al.
Journal of inorganic biochemistry, 121, 134-144 (2013-02-05)
Novel square-planar palladium(II) complexes with O-N-N-O-type ligands H4mda (H4mda=malamido-N,N'-diacetic acid) and H4obp (H4obp=oxamido-N,N'-di-3-propionic acid) were prepared and characterized. The ligands coordinate to the palladium(II) ion via two pairs of deprotonated ligating atoms with square chelation. A four coordinate, square-planar geometry
Zhe Li et al.
Nucleic acids research, 42(6), 4068-4079 (2013-12-29)
G-quadruplex-forming oligonucleotides containing modified nucleotide chemistries have demonstrated promising pharmaceutical potential. In this work, we systematically investigate the effects of sugar-modified guanosines on the structure and stability of a (4+0) parallel and a (3+1) hybrid G-quadruplex using over 60 modified
Jeffery T Davis et al.
Chemical Society reviews, 36(2), 296-313 (2007-02-01)
Nature's use of a simple genetic code to enable life's complex functions is an inspiration for supramolecular chemistry. DNA nucleobases carry the key information utilizing a variety of cooperative and non-covalent interactions such as hydrophobic, van der Waals, pi-pi stacking

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