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About This Item
經驗公式（希爾表示法）:
C10H12ClNO2 · HCl
CAS號碼:
分子量：:
250.12
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.32
推薦產品
形狀
solid
品質等級
光學活性
[α]28/D +3.8°, c = 0.9 in methanol(lit.)
儲存條件
desiccated
顏色
white
溶解度
DMSO: >20 mg/mL
H2O: 26 mg/mL (Solutions may be stored for several weeks at 4 °C.)
SMILES 字串
Cl[H].NC[C@H](CC(O)=O)c1ccc(Cl)cc1
InChI
1S/C10H12ClNO2.ClH/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14;/h1-4,8H,5-6,12H2,(H,13,14);1H/t8-;/m0./s1
InChI 密鑰
WMNUVYYLMCMHLU-QRPNPIFTSA-N
基因資訊
human ... GABBR1(2550)
mouse ... GABBR1(54393)
rat ... GABBR1(81657)
應用
R(+)-盐酸巴氯芬已用作GABAB受体激动剂，以研究其对大鼠模型中M43068诱导的镇痛作用的影响。它还被用作GABAB受体激动剂，以研究其对鼠纹状体中安非他命诱导的行为和神经化学反应的影响。
生化／生理作用
巴氯芬是一种γ-氨基丁酸（GABA）的衍生物，可用作4-氨基丁酸受体（GABAB）激动剂。它与GABA受体立体定向相互作用并表现出抗痉挛作用。巴氯芬对三叉神经痛和脊柱痉挛的阵发性疼痛有治疗作用。R(+)-巴氯芬是一种活性更强的对映体。
其他說明
对映异构体与 R（−）-巴氯芬游离碱相同。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
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