推薦產品
生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous glycerol solution
物種活性
human
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
基因資訊
human ... MAPK7(5598)
一般說明
Extracellular Signal-Regulated Kinases (ERKs) are proteins that belong to mitogen-activated protein kinase superfamily (MAPK) and have a pivotal role in cell cycle, differentiation, transcription and learning and memory through signal transduction in the cytoplasm and the nucleus. ERK5 MAP kinase cascade has a crucial functions like- induction of special form of cardiac hypertrophy, enhanced neuronal survival and early steps of muscle cell differentiation. Anti-phospho-ERK5 (pThr218/pTyr220) antibody can be used in immunostaining. Rabbit anti- phospho-ERK5 (pThr218/pTyr220) antibody reacts specifically with ERK5 (88 kD) of human.
免疫原
Synthetic phosphopeptide derived from the region of human ERK5 that contains threonine 218 and tyrosine 220. This sequence is conserved in human and mouse.
應用
Each vial contains enough material for 10 blots. The end user should determine the correct working dilution for their process.
外觀
Solution in Dulbecco′s PBS, pH 7.3, with 50% glycerol, 1 mg/ml BSA and ≤ 0.1% sodium azide.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
A Karihaloo et al.
The Journal of biological chemistry, 276(12), 9166-9173 (2000-12-29)
Cells derived from the inner medullary collecting duct undergo in vitro branching tubulogenesis to both the c-met receptor ligand hepatocyte growth factor (HGF) as well as epidermal growth factor (EGF) receptor ligands. In contrast, many other cultured renal epithelial cells
M Janulis et al.
Molecular and cellular biology, 21(6), 2235-2247 (2001-03-10)
The proto-oncogene Raf is a major regulator of growth and differentiation. Previous studies from a number of laboratories indicate that Raf activates a signaling pathway that is independent of the classic MEK1,2-ERK1,2 cascade. However, no other signaling cascade downstream of
Rui-min Wang et al.
Neuroscience letters, 357(1), 13-16 (2004-03-24)
Activation (phosphorylation) and the possible mechanism of extracellular signal-regulated kinase 5 (ERK5) were evaluated after cerebral ischemia-reperfusion (I/R) in the hippocampus in a four-vessel occlusion model of Sprague-Dawley rats. Western blotting showed that ERK5 was strongly activated from 10 min
Rui-Min Wang et al.
Life sciences, 79(19), 1839-1846 (2006-07-25)
Accumulating evidence implicates activation (phosphorylation) of mitogen-activated protein kinases (MAPK) during nonlethal ischemic preconditioning in the protection of hippocampal CA1 neuron against subsequent ischemic events. In this paper, we undertook to identify the role of extracellular signal regulated kinase (ERK)
Li-Na Yu et al.
Pain physician, 20(4), E563-E574 (2017-05-24)
There are numerous studies implicating that EphB receptors and ephrinB ligands play important roles in modulating the transduction of spinal nociceptive information. EphrinB-EphB signaling may contribute to hyperalgesia via various kinds of downstream molecules, the mechanisms of which have not
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