E7131

[D-Ala², D-Leu⁵]-脑啡肽 乙酸盐

≥95% (HPLC)

• 同義詞: DADLE
• 經驗公式（希爾表示法）: C₂₉H₃₉N₅O₇
• CAS號碼: 94825-57-7
• 分子量：: 569.65
• MDL號碼: MFCD00133947
• 分類程式碼代碼: 12352209
• PubChem物質ID: 329799004
• NACRES: NA.32

屬性

• 品質等級: 200
• 化驗: ≥95% (HPLC)
• 儲存溫度: −20°C
• SMILES 字串: CC(O)=O.CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(O)=O
• InChI: 1S/C29H39N5O7.C2H4O2/c1-17(2)13-24(29(40)41)34-28(39)23(15-19-7-5-4-6-8-19)33-25(36)16-31-26(37)18(3)32-27(38)22(30)14-20-9-11-21(35)12-10-20;1-2(3)4/h4-12,17-18,22-24,35H,13-16,30H2,1-3H3,(H,31,37)(H,32,38)(H,33,36)(H,34,39)(H,40,41);1H3,(H,3,4)/t18-,22+,23+,24-;/m1./s1
• InChI 密鑰: YRZBXSPTRALQEX-IIKZURRYSA-N
• 基因資訊: human ... OPRD1(4985) ; mouse ... OPRD1(18386) ; rat ... OPRD1(24613)

描述

Amino Acid Sequence

Tyr-Ala-Gly-Phe-Leu

一般說明

[D-Ala², D-Leu⁵]-Enkephalin acetate salt, also called DADLE, is an analog of endogenous δ-opioid peptide encephalin, and is metabolically stable.

應用

[D-Ala², D-Leu⁵]-Enkephalin or DADLE has been used for use in immunocomplex kinetic assay, to determine the activation of p70^s6k by DADLE in the cell clones D2 and DOE and in non-transfected parental Rat-1 fibroblasts and to assess the analgesic effect of WIN55,212-2 in mice.

生化／生理作用

原型 δ-激动剂；比 Leu-脑啡肽和 Met-脑啡肽更强效、更具选择性；镇痛效果与 β-内啡肽相当

Prototypical δ-agonist; more potent and selective than Leu-enkephalin and Met-enkephalin.

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Gloves, type N95 (US)