E0907
Anti-phospho-Epidermal Growth Factor Receptor (pTyr845) antibody produced in rabbit
affinity isolated antibody, lyophilized powder
同義詞:
Anti-phospho-EGFR (pTyr845)
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About This Item
MDL號碼:
分類程式碼代碼:
51111800
共軛:
unconjugated
application:
FACS
IHC
WB
IHC
WB
無性繁殖:
polyclonal
物種活性:
human
citations:
3
技術:
flow cytometry: 5 μg/mL
immunohistochemistry: 15 μg/mL
western blot: 0.5 μg/mL
immunohistochemistry: 15 μg/mL
western blot: 0.5 μg/mL
生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
lyophilized powder
物種活性
human
技術
flow cytometry: 5 μg/mL
immunohistochemistry: 15 μg/mL
western blot: 0.5 μg/mL
UniProt登錄號
儲存溫度
−20°C
基因資訊
human ... EGFR(1956)
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免疫原
purified, synthetic phosphopeptide corresponding to residues surrounding tyrosine 845 of human epidermal growth factor receptor.
生化／生理作用
EGFR is a transmembrane glycoprotein that binds to the EGF family. It is a pivotal regulator of cell proliferation, growth, differentiation and DNA repair after radiation-induced damage. Mutations in the gene encoding EGFR are associated with a number of malignancies including lung cancer and colorectal cancer. Phosphorylation of Tyr845 is associated with EGFR mutation and serves as a surrogate marker.
外觀
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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產品號碼
描述
訂價
儲存類別代碼
13 - Non Combustible Solids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
Hideki Endoh et al.
Lung cancer (Amsterdam, Netherlands), 63(2), 241-246 (2008-07-01)
Overexpression of EGFR is found in several malignancies including lung cancers. Recently, EGFR mutation has been shown to correlate with responsiveness to tyrosine kinase inhibitors (TKI). Although antibodies against phophorylated EGFR have been used in vitro, phosphorylated EGFR has yet
Jing Bai et al.
Asian Pacific journal of cancer prevention : APJCP, 13(10), 4879-4881 (2012-12-19)
Epidermal growth factor receptor (EGFR) overexpression is associated with resistance to chemotherapy and radiotherapy. The EGFR modulates DNA repair after radiation-induced damage through an association with the catalytic subunit of DNA protein kinase. DNA double-strand breaks (DSBs) are the most
Thu H Truong et al.
Biochemistry, 51(50), 9954-9965 (2012-11-29)
Epidermal growth factor receptor (EGFR) exemplifies the family of receptor tyrosine kinases that mediate numerous cellular processes, including growth, proliferation, and differentiation. Moreover, gene amplification and EGFR mutations have been identified in a number of human malignancies, making this receptor
Javier Palazuelos et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(36), 11884-11896 (2014-09-05)
Several studies have elucidated the significance of a disintegrin and metalloproteinase proteins (ADAMs) in PNS myelination, but there is no evidence if they also play a role in oligodendrogenesis and CNS myelination. Our study identifies ADAM17, also called tumor necrosis
Lakshmi Reddy Bollu et al.
Cell cycle (Georgetown, Tex.), 13(15), 2415-2430 (2014-12-09)
Increased expressions of fatty acid synthase (FASN) and epidermal growth factor receptor (EGFR) are common in cancer cells. De novo synthesis of palmitate by FASN is critical for the survival of cancer cells via mechanisms independent of its role as
我們的科學家團隊在所有研究領域都有豐富的經驗，包括生命科學、材料科學、化學合成、色譜、分析等.
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