E0656

ER-27319

≥98% (HPLC), solid

• 同義詞: 10-(3-Aminopropyl)-3,4-dimethyl-9-acridone oxalate
• 經驗公式（希爾表示法）: C₂₀H₂₂N₂O₅
• CAS號碼: 201010-95-9
• 分子量：: 370.40
• MDL號碼: MFCD07784502
• 分類程式碼代碼: 12352200
• PubChem物質ID: 24724472
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: solid
• 溶解度: DMSO: 28 mg/mL
• 儲存溫度: 2-8°C
• SMILES 字串: OC(=O)C(O)=O.Cc1ccc2C(=O)c3ccccc3N(CCCN)c2c1C
• InChI: 1S/C18H20N2O.C2H2O4/c1-12-8-9-15-17(13(12)2)20(11-5-10-19)16-7-4-3-6-14(16)18(15)21;3-1(4)2(5)6/h3-4,6-9H,5,10-11,19H2,1-2H3;(H,3,4)(H,5,6)
• InChI 密鑰: IIELZHYJYZBSGG-UHFFFAOYSA-N

描述

生化／生理作用

ER-27319 inhibits Syk activation with an IC₅₀ = 10 μM. ER-27319 inhibits Syk by preventing the phosphorylated ITAM domain of FcεRI γ from activating Syk. ER-27319 does NOT inhibit previously activated Syk.

Selective Syk inhibitor. Induces tyrosine phosphorylation of Syk that has been demonstrated as critical for degranulation.

特點和優勢

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安全資訊

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H302 + H312
• 防範說明: P264 - P280 - P301 + P312 - P302 + P352 + P312 - P362 + P364 - P501
• 危險分類: Acute Tox. 4 Dermal - Acute Tox. 4 Oral
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable