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D9571

Sigma-Aldrich

Dolasetron mesylate hydrate

≥98% (HPLC), powder

同義詞:

Anzemet hydrate, Dolasetron methanesulfonate hydrate

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About This Item

經驗公式(希爾表示法):
C19H20N2O3 · CH4O3S · xH2O
CAS號碼:
分子量::
420.48 (anhydrous basis)
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

品質等級

化驗

≥98% (HPLC)

形狀

powder

顏色

white to off-white

溶解度

H2O: >30 mg/mL

起源

Sanofi Aventis

儲存溫度

2-8°C

SMILES 字串

O.CS(O)(=O)=O.O=C1CN2[C@@H]3C[C@H](C[C@H]2CC1C3)OC(=O)c4c[nH]c5ccccc45

InChI

1S/C19H20N2O3.CH4O3S.H2O/c22-18-10-21-12-5-11(18)6-13(21)8-14(7-12)24-19(23)16-9-20-17-4-2-1-3-15(16)17;1-5(2,3)4;/h1-4,9,11-14,20H,5-8,10H2;1H3,(H,2,3,4);1H2/t11?,12-,13+,14+;;

InChI 密鑰

QTFFGPOXNNGTGZ-BHSFMSKKSA-N

生化/生理作用

Dolasetron mesylate hydrate is a highly specific and selective serotonin 5-HT3 receptor antagonist, not shown to have activity at other known serotonin receptors and with low affinity for dopamine receptors.

特點和優勢

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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存取文件庫

Christopher M Peters et al.
Brain research, 1352, 83-93 (2010-07-20)
The balance between descending inhibition and facilitation is thought to be disturbed in chronic pain states. Increased facilitation by spinally released serotonin has been suggested by demonstration that mechanically evoked neuronal responses of wide dynamic range neurons are inhibited by
Sarah Turner et al.
Journal of clinical anesthesia, 19(8), 622-625 (2007-12-18)
A 52-year-old woman with hypertension and Graves' disease was scheduled for surgical removal of a meningioma. Intraoperative events were significant for hypotension requiring a vasopressin infusion. Prophylactic dolasetron was administered to the patient before emergence. The patient's trachea was easily
Dolasetron and QT interval.
C Page et al.
Emergency medicine journal : EMJ, 25(10), 706-706 (2008-10-10)
Antiemetic agents.
Gail Wilkes
Oncology (Williston Park, N.Y.), 21(8 Suppl), 48-48 (2007-09-12)
[Palonosetron in the prevention of chemotherapy-induced nausea and vomiting (CINV) in Italy: pharmacologic, clinical and economic aspects].
Lorenzo Pradelli et al.
Tumori, 94(2), suppl 26-suppl 32 (2008-06-21)

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