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重要文件

D8783

Sigma-Aldrich

7-脱氮-2′-脱氧鸟苷5′-三磷酸 锂盐

10 mM in H2O

同義詞:

−N7-dGTP, 7-脱氮-dGTP

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About This Item

經驗公式(希爾表示法):
C11H17N4O13P3
CAS號碼:
分子量::
506.19
MDL號碼:
分類程式碼代碼:
41106305
PubChem物質ID:
NACRES:
NA.52

生物源

Porcine muscle
rabbit muscle

品質等級

化驗

≥95% (HPLC)

形狀

liquid

濃度

10 mM in H2O

顏色

colorless

運輸包裝

dry ice

儲存溫度

−20°C

SMILES 字串

NC1=NC(=O)c2ccn(C3CC(O)C(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O3)c2N1

InChI

1S/C11H17N4O13P3/c12-11-13-9-5(10(17)14-11)1-2-15(9)8-3-6(16)7(26-8)4-25-30(21,22)28-31(23,24)27-29(18,19)20/h1-2,6-8,16H,3-4H2,(H,21,22)(H,23,24)(H2,18,19,20)(H3,12,13,14,17)

InChI 密鑰

DLLXAZJTLIUPAI-UHFFFAOYSA-N

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應用

7-脱氮-2′-脱氧鸟苷-5′-三磷酸锂盐已用作裂解剂,评估其直接细胞裂解的效率、RNA稳定性,以及在分析少量细胞样品时与下游逆转录定量实时PCR的兼容性。

生化/生理作用

7-脱氮-2′-脱氧鸟苷-5′-三磷酸 (7-deaza-dGTP) 与天然底物 dGTP 竞争并阻断端粒酶活性。该核苷酸掺入端粒后,会即刻改变端粒的二级结构,使端粒酶难以识别它,无法进一步合成端粒。这种dGTP类似物可与常规碱基弱配对,最大限度地减少DNA二级结构的形成,同时成为DNA聚合酶的良好底物。7-deaza-dGTP与二甲基亚砜 (DMSO) 和甜菜碱结合使用可增强富含GC的 DNA 序列的聚合酶链式反应 (PCR) 扩增。

儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 2

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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存取文件庫

Roger Pamphlett et al.
PloS one, 8(7), e70007-e70007 (2013-07-31)
Gene mutations that preferentially affect the CNS have been implicated in a number of neurological disorders. This leads to the possibility that a disease-causing mutation present only in CNS tissues could be missed if it were tested in a blood
7-Deaza-2-deoxyguanosine allows PCR and sequencing reactions from CpG islands
Jung A, et al.
Molecular Pathology, 55(1), 55-55 (2002)
Andreas Blecha et al.
Microbial cell factories, 4, 28-28 (2005-10-06)
Native as well as recombinant bacterial cell surface layer (S-layer) protein of Geobacillus (G.) stearothermophilus ATCC 12980 assembles to supramolecular structures with an oblique symmetry. Upon expression in E. coli, S-layer self assembly products are formed in the cytosol. We
Tatsuo Hata et al.
The Journal of molecular diagnostics : JMD, 20(1), 46-55 (2017-12-13)
Telomere end-to-end fusions are an important source of chromosomal instability that arise in cells with critically shortened telomeres. We developed a nested real-time quantitative PCR method for telomere fusion detection in pancreatic ductal adenocarcinomas, intraductal papillary mucinous neoplasms (IPMNs), and
Emmanuel F Mongodin et al.
PLoS genetics, 2(12), e214-e214 (2006-12-30)
Arthrobacter sp. strains are among the most frequently isolated, indigenous, aerobic bacterial genera found in soils. Member of the genus are metabolically and ecologically diverse and have the ability to survive in environmentally harsh conditions for extended periods of time.

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