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Key Documents

D7696

Sigma-Aldrich

去甲氧基姜黄素

≥98% (HPLC), powder, LPS-induced nitric oxide (NO) production inhibitor

同義詞:

(E,E)1-(4-羟基-3-甲氧基苯基)-7-(4-羟基苯基)-1,6-庚二烯-3,5-二酮, 单脱甲氧基姜黄素, 去甲氧基姜黄素, 姜黄素 II

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About This Item

經驗公式(希爾表示法):
C20H18O5
CAS號碼:
分子量::
338.35
MDL號碼:
分類程式碼代碼:
12352205
PubChem物質ID:
NACRES:
NA.77

product name

去甲氧基姜黄素, ≥98% (HPLC)

品質等級

化驗

≥98% (HPLC)

形狀

powder

儲存條件

protect from light

顏色

orange

溶解度

DMSO: ≥10 mg/mL

儲存溫度

2-8°C

SMILES 字串

COc1cc(\C=C\C(=O)CC(=O)\C=C\c2ccc(O)cc2)ccc1O

InChI

1S/C20H18O5/c1-25-20-12-15(6-11-19(20)24)5-10-18(23)13-17(22)9-4-14-2-7-16(21)8-3-14/h2-12,21,24H,13H2,1H3/b9-4+,10-5+

InChI 密鑰

HJTVQHVGMGKONQ-LUZURFALSA-N

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生化/生理作用

脱甲氧基姜黄素 (DMC) 是一种衍生物或姜黄素,是从 姜黄中分离得到的姜黄素产品的主要活性成分之一。DMC通过阻止NF-kB激活来抑制LPS诱导的一氧化氮(NO)产生以及RAW264.7细胞中iNOS和COX2的表达。在LPS处理的大鼠小胶质细胞中,DMC也抑制NF-kB对iNOS,TNFα和IL-1β的表达。DMC通过抑制NF-kB抑制MDA-MB-231人乳腺癌细胞中MMP和ICAM-1的表达。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號,寫有 ‘Lot’或‘Batch’.。

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存取文件庫

Lijia Zhang et al.
International immunopharmacology, 10(3), 331-338 (2009-12-19)
Our previous report has showed that demethoxycurcumin (DMC), a natural derivative of curcumin (Cur), exhibited stronger inhibitory activity on nitric oxide (NO) and tumor necrosis factor-alpha (TNF-alpha) production compared with Cur in lipopolysaccharide (LPS) activated rat primary microglia. In the
T Ahmed et al.
Neuroscience, 169(3), 1296-1306 (2010-06-12)
Alzheimer's disease (AD) is a neurodegenerative disease. There are a limited number of therapeutic options available for the treatment of AD. Curcuminoids (a mixture of bisdemethoxycurcumin, demethoxycurcumin and curcumin) is the main chemical constituent found in turmeric, a well known
Hye Jin Kim et al.
Phytochemical analysis : PCA, 20(5), 372-377 (2009-06-18)
The new ion source technique, direct analysis in real time (DART) atmospheric pressure ionisation, allows high resolution mass measurements of gas, liquid and solid samples. As DART-MS produces [M + H](+) molecular ions of most compounds, relatively simple and clear
R Douglas Shytle et al.
Current Alzheimer research, 6(6), 564-571 (2009-09-01)
Inhibition of beta-amyloid (A beta) accumulation and A beta fibril (fA beta) formation from A beta are attractive therapeutic targets for the treatment of Alzheimer's disease (AD). While previous studies have shown anti-amyloidogenic effects of curcumin in vitro and in
Umang Singh et al.
Free radical research, 45(3), 317-325 (2010-11-03)
Three curcumin analogues viz., bisdemethoxy curcumin, monodemethoxy curcumin, and dimethoxycurcumin that differ at the phenolic substitution were synthesized. These compounds have been subjected for free radical reactions with DPPH radicals, superoxide radicals (O(2)(•-)), singlet oxygen ((1)O(2)) and peroxyl radicals (CCl(3)O(2)(•))

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