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Merck
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重要文件

D7003

Sigma-Aldrich

DL-Dihydroorotic acid

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About This Item

經驗公式(希爾表示法):
C5H6N2O4
CAS號碼:
分子量::
158.11
MDL號碼:
分類程式碼代碼:
12352204
PubChem物質ID:

形狀

powder

SMILES 字串

OC(=O)C1CC(=O)NC(=O)N1

InChI

1S/C5H6N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h2H,1H2,(H,9,10)(H2,6,7,8,11)

InChI 密鑰

UFIVEPVSAGBUSI-UHFFFAOYSA-N

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


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分析證明 (COA)

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Timo Heikkilä et al.
Journal of medicinal chemistry, 50(2), 186-191 (2007-01-19)
Pyrimidine biosynthesis presents an attractive drug target in malaria parasites due to the absence of a pyrimidine salvage pathway. A set of compounds designed to inhibit the Plasmodium falciparum pyrimidine biosynthetic enzyme dihydroorotate dehydrogenase (PfDHODH) was synthesized. PfDHODH-specific inhibitors with
Joana Costeira-Paulo et al.
Cell chemical biology, 25(3), 309-317 (2018-01-24)
The interactions between proteins and biological membranes are important for drug development, but remain notoriously refractory to structural investigation. We combine non-denaturing mass spectrometry (MS) with molecular dynamics (MD) simulations to unravel the connections among co-factor, lipid, and inhibitor binding
Ceyhun Bereketoglu et al.
Physiological genomics, 49(10), 549-566 (2017-09-10)
Bioaccumulative environmental estrogen, nonylphenol (NP; 4-nonylphenol), is widely used as a nonionic surfactant and can affect human health. Since genomes of
Daniel Ken Inaoka et al.
Biochemistry, 47(41), 10881-10891 (2008-09-24)
Dihydroorotate dehydrogenase (DHOD) from Trypanosoma cruzi (TcDHOD) is a member of family 1A DHOD that catalyzes the oxidation of dihydroorotate to orotate (first half-reaction) and then the reduction of fumarate to succinate (second half-reaction) in the de novo pyrimidine biosynthesis
Idalia Sariego et al.
Parasitology international, 55(1), 11-16 (2005-09-21)
Dihydroorotate dehydrogenase (DHOD) is the fourth enzyme in the de novo pyrimidine biosynthetic pathway and is essential in Trypanosoma cruzi, the parasitic protist causing Chagas' disease. T. cruzi and human DHOD have different biochemical properties, including the electron acceptor capacities

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