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重要文件

D3669

Sigma-Aldrich

3,3′-二硫代二丙酸二(N-羟基丁二酰亚胺酯)

powder

同義詞:

DTSP, Lomant’s试剂, 二(N-琥珀酰亚胺基)-3,3′-二硫代二丙酸酯, 二硫代双(琥珀酰亚胺丙酸酯)

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About This Item

經驗公式(希爾表示法):
C14H16N2O8S2
CAS號碼:
分子量::
404.42
Beilstein:
1518074
EC號碼:
MDL號碼:
分類程式碼代碼:
12352106
PubChem物質ID:
NACRES:
NC.07

形狀

powder

品質等級

反應適用性

reagent type: cross-linking reagent

溶解度

chloroform: 50 mg/mL
DMF: soluble
acetone: soluble

儲存溫度

−20°C

SMILES 字串

O=C(CCSSCCC(=O)ON1C(=O)CCC1=O)ON2C(=O)CCC2=O

InChI

1S/C14H16N2O8S2/c17-9-1-2-10(18)15(9)23-13(21)5-7-25-26-8-6-14(22)24-16-11(19)3-4-12(16)20/h1-8H2

InChI 密鑰

FXYPGCIGRDZWNR-UHFFFAOYSA-N

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一般說明

3,3'-二硫代二丙酸二(N-羟基琥珀酰亚胺酯)(DSP)是一种含有可裂解二硫键的同双功能交联剂。它通常在pH 7.5(6.5-8.5)的缓冲液中与含有伯胺的分子通过酰胺键发生偶联。

應用

3,3'-二硫代二丙酸二(N-羟基琥珀酰亚胺酯)(DSP)已被用作蛋白质交联剂。

特點和優勢

通过温和还原,可使二硫键裂解。

注意

在偶联反应过程中避免使用还原剂。

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


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分析證明 (COA)

Lot/Batch Number

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Protein phosphatases 2C regulate the activation of the Snf1-related kinase OST1 by abscisic acid in Arabidopsis.
Vlad F
Plant Cell, 21, 3170-3170 (2009)
M Darder et al.
Analytical chemistry, 71(24), 5530-5537 (2000-01-07)
Exposure of gold surfaces to solutions of dithiobis N-succinimidyl propionate (DTSP) gives rise to the modification of the surface with N-succinimidyl-3-thiopropionate (NSTP) which can, in turn, react with amino groups allowing for the covalent immobilization of enzymes such as horseradish
N S Green et al.
Protein science : a publication of the Protein Society, 10(7), 1293-1304 (2001-06-23)
Homobifunctional chemical cross-linking reagents are important tools for functional and structural characterization of proteins. Accurate measures of the lengths of these molecules currently are not available, despite their widespread use. Stochastic dynamics calculations now provide quantitative measures of the lengths
Michael Neu et al.
Biomacromolecules, 7(12), 3428-3438 (2006-12-13)
Stabilized PEI/DNA polyplexes were generated by cross-linking PEI with biodegradable disulfide bonds. The reaction conversion of different PEIs with the amine reactive cross-linker dithiobis(succinimidyl propionate) (DSP) was investigated, and the molecular weight of the reaction products was identified. Light scattering
Antonio N Calabrese et al.
Rapid communications in mass spectrometry : RCM, 27(1), 238-248 (2012-12-15)
It has been shown that the disulfide moiety in the chemical cross-linking reagent dithiobis(succinimidyl)propionate (DSP), which is similar in structure to the natural cystine disulfide, cleaves preferentially to the peptide backbone in the negative ion mode. However, the tandem mass

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