D1944

D4476

≥98% (HPLC), solid

• 同義詞: 4-(4-(2,3-Dihydrobenzo[1,4]dioxin-6-yl)-5-pyridin-2-yl-1H-imidazol-2-yl)benzamide
• 經驗公式（希爾表示法）: C₂₃H₁₈N₄O₃
• CAS號碼: 301836-43-1
• 分子量：: 398.41
• 分類程式碼代碼: 12352200
• PubChem物質ID: 329798715
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: solid
• 顏色: light yellow
• 溶解度: DMSO: ~20 mg/mL; H₂O: insoluble
• 起源: GlaxoSmithKline
• 儲存溫度: 2-8°C
• SMILES 字串: NC(=O)c1ccc(cc1)-c2nc(-c3ccccn3)c([nH]2)-c4ccc5OCCOc5c4
• InChI: 1S/C23H18N4O3/c24-22(28)14-4-6-15(7-5-14)23-26-20(21(27-23)17-3-1-2-10-25-17)16-8-9-18-19(13-16)30-12-11-29-18/h1-10,13H,11-12H2,(H2,24,28)(H,26,27)
• InChI 密鑰: DPDZHVCKYBCJHW-UHFFFAOYSA-N

描述

應用

D4476 has been used as a casein kinase I inhibitor (CKI) in various experiments.

生化／生理作用

D4476 may prevent or enhance apoptosis. It triggers tumor suppressor p53 and impairs transcription factor E2F-1.

D4476 is a potent, selective ATP-competitive inhibitor of CK1 (casein kinase 1).

特點和優勢

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Gloves, type N95 (US)