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Merck
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重要文件

D1634

Sigma-Aldrich

薯蓣皂苷元

≥93%

同義詞:

(25R)-5-螺甾烯-3β-醇, 3β-羟基-5-螺甾烯, 薯蓣皂素

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About This Item

經驗公式(希爾表示法):
C27H42O3
CAS號碼:
分子量::
414.62
Beilstein:
94582
EC號碼:
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

品質等級

化驗

≥93%

形狀

powder

SMILES 字串

[H][C@]12C[C@@]3([H])[C@]4([H])CC=C5C[C@@H](O)CC[C@]5(C)[C@@]4([H])CC[C@]3(C)[C@@]1([H])[C@H](C)[C@@]6(CC[C@@H](C)CO6)O2

InChI

1S/C27H42O3/c1-16-7-12-27(29-15-16)17(2)24-23(30-27)14-22-20-6-5-18-13-19(28)8-10-25(18,3)21(20)9-11-26(22,24)4/h5,16-17,19-24,28H,6-15H2,1-4H3/t16-,17+,19+,20-,21+,22+,23+,24+,25+,26+,27-/m1/s1

InChI 密鑰

WQLVFSAGQJTQCK-VKROHFNGSA-N

基因資訊

human ... UGT1A4(54657)

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一般說明

薯蓣皂苷元是一种三萜类化合物,也是薯蓣皂苷的糖基衍生物。 它存在于山药、胡芦巴(Trigonella foenum-graecum)和闭鞘姜(Costus speciosus)等植物中。

應用

薯蓣皂苷元已被用于:
  • 作为分析毛瓣无患子所含总皂苷的标准品
  • 口服给予大鼠,以研究其对致动脉粥样化饮食诱导的心脏、肝脏和大脑炎症介质产生的抵抗作用
  • 作为标准化合物,用于检测鹰嘴豆和蒺藜的皂苷含量

生化/生理作用

薯蓣皂苷元能诱导结肠癌细胞凋亡以及诱导骨肉瘤细胞的凋亡、细胞周期停滞和环加氧酶活性。它是类固醇药物生产的前体。薯蓣皂苷元已被证明能够通过刺激胆汁排泄来促进胆固醇生成。它能够影响脂氧合酶诱导的人红白血病细胞系分化。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 2

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 43(6), 2434-2445 (2017-10-27)
We investigated how diosgenin, a steroidal sapogenin, has anti-tumor necrosis factor-α (TNF-α) effects in human aortic endothelial cells (HAECs). Tumor necrosis factor receptor 1 (TNFR1) was assessed by Western blot analysis. Intracellular Ca2+ was measured using Fluo-4 AM. Immunofluorescence staining

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