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C9487

Sigma-Aldrich

抗-降钙素基因相关肽单克隆抗体 小鼠抗

clone CD8, purified immunoglobulin, buffered aqueous solution

同義詞:

抗 CGRP

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About This Item

MDL號碼:
MFCD00162203
分類程式碼代碼:
12352203
NACRES:
NA.41

生物源

mouse

品質等級

200

共軛

unconjugated

抗體表格

purified immunoglobulin

抗體產品種類

primary antibodies

無性繁殖

CD8, monoclonal

形狀

buffered aqueous solution

物種活性

guinea pig, human

技術

immunocytochemistry: suitable
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:200-1:1,000 using ovenight incubation at 4 °C and sections that have been protease-digested or processed by high temperature antigen retrieval
indirect immunofluorescence: 1:500 using overnight incubation at 4 °C

同型

IgG1

UniProt登錄號

P01258

運輸包裝

dry ice

儲存溫度

−20°C

目標翻譯後修改

unmodified

基因資訊

human ... CALCA(796)
rat ... Calca(24241)

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一般說明

降钙素基因相关肽（CGRP）是一种血管舒张剂，属于降钙素肽家族。它由周围和中枢神经紧张系统的运动神经元产生。CGRP有两种形式，α和β，它们具有相似的功能。CGRP的作用是由降钙素受体样受体（CRLR）和受体活性修饰蛋白1（RAMP1）形成的G蛋白偶联受体异二聚体介导的。 CGRP在神经紧张、内分泌、免疫和心血管系统中具有多种生物学作用。 多项研究表明CGRP与偏头痛的病理生理有关，并且正在探索CGRP的拮抗剂作为治疗的选择。
单克隆抗降钙素基因相关肽（CGRP）可识别人和豚鼠CGRP。与大鼠CGRP无交叉反应。

免疫原

对应于大鼠α−降钙素基因相关肽（CGRP）C末端的肽。

應用

抗降钙素基因相关肽（CGRP）抗体适用于使用福尔马林固定、石蜡包埋切片或低温恒温器组织切片以1:200至1:1000的工作抗体稀释度进行免疫组化。该抗体可用于免疫荧光，其工作稀释度为1:500。

外觀

含1%BSA和≤0.1%叠氮化钠的PBS溶液

免責聲明

除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

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儲存類別代碼

10 - Combustible liquids

水污染物質分類（WGK）

WGK 1

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

分析證明 (COA)

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存取文件庫

Ana Recober et al.
Current opinion in neurology, 22(3), 241-246 (2009-05-13)
This review includes the most relevant and recent studies on the biology of calcitonin gene-related peptide (CGRP) as it pertains to primary headaches and particularly to migraine. Especial attention was given to those published within the last year. The development
Udayasankar Arulmani et al.
European journal of pharmacology, 500(1-3), 315-330 (2004-10-07)
Migraine is a common neurological disorder that is associated with an increase in plasma calcitonin gene-related peptide (CGRP) levels. CGRP, a neuropeptide released from activated trigeminal sensory nerves, dilates intracranial blood vessels and transmits vascular nociception. Therefore, it is propounded
C Juaneda et al.
Trends in pharmacological sciences, 21(11), 432-438 (2000-12-21)
Calcitonin gene-related peptides (alpha and beta isoforms), better known as CGRPalpha and CGRPbeta, were isolated twenty years ago. In fact, these were the first peptides to be characterized using a molecular cloning strategy, which is not the traditional approach of
T Esfandyari et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 14(10), 1439-1446 (2000-07-06)
The receptor responsible for CGRP-induced ion transport and permeability was examined in tissues from animals treated 7 days previously with trinitrobenzenesulfonic acid to induce colitis or in controls. CGRP caused a concentration-dependent increase in short circuit current (I(sc), EC(50) 21
S G Amara et al.
Science (New York, N.Y.), 229(4718), 1094-1097 (1985-09-13)
As a consequence of alternative RNA processing events, a single rat gene can generate messenger RNA's (mRNA's) encoding either calcitonin or a neuropeptide referred to as alpha-type calcitonin gene-related peptide (alpha-CGRP). An mRNA product of a related gene has been
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