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C8977

Sigma-Aldrich

单克隆抗-CREB 兔抗

clone 48H2, purified immunoglobulin, buffered aqueous glycerol solution

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About This Item

MDL號碼:
MFCD01092316
分類程式碼代碼:
12352203
NACRES:
NA.41

生物源

rabbit

品質等級

200

共軛

unconjugated

抗體表格

purified immunoglobulin

抗體產品種類

primary antibodies

無性繁殖

48H2, monoclonal

形狀

buffered aqueous glycerol solution

分子量

antigen 43 kDa

物種活性

rat, human, monkey, mouse

技術

ChIP: 1:50
flow cytometry: 1:400
immunocytochemistry: 1:800
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:6,400
immunohistochemistry (frozen sections): 1:6,400
immunoprecipitation (IP): 1:250
indirect immunofluorescence: 1:800
western blot: 1:1,000 using extracts from SK-N-MC cells treated with forskolin or FGF

同型

IgG

UniProt登錄號

P16220

運輸包裝

wet ice

儲存溫度

−20°C

目標翻譯後修改

unmodified

基因資訊

human ... CREB1(1385)
mouse ... Creb1(12912)
rat ... Creb1(81646)

相關類別

特異性

检测总 CREB 蛋白的内源水平。

免疫原

人 CREB 氨基末端的特异性重组蛋白。

外觀

10 mM HEPES 钠溶液，pH 7.5，含有 150 mM 氯化钠、100μ g/mL 牛血清白蛋白和< 0.02% 叠氮化钠和 50% 甘油。

法律資訊

使用 Epitomics® Technology 生产的兔单克隆抗体，美国专利号 5,675,063。

免責聲明

除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

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儲存類別代碼

10 - Combustible liquids

水污染物質分類（WGK）

WGK 2

閃點（°F）

Not applicable

閃點（°C）

Not applicable

分析證明 (COA)

輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。

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存取文件庫

Min Gyu Lee et al.
The Journal of biological chemistry, 278(42), 41047-41058 (2003-08-02)
A common signature of many cancers is a high glucose catabolic rate frequently dependent on the overexpression of Type II hexokinase (HKII), a mitochondrial bound enzyme that also suppresses cell death. As the tumor HKII promoter plays a significant role
CREB: a mediator of long-term memory from mollusks to mammals.
D A Frank et al.
Cell, 79(1), 5-8 (1994-10-07)
J C Yin et al.
Cell, 81(1), 107-115 (1995-04-07)
Genetic studies of memory formation in Drosophila have revealed that the formation of a protein synthesis-dependent long-term memory (LTM) requires multiple training sessions. LTM is blocked specifically by induced expression of a repressor isoform of the cAMP-responsive element-binding protein (CREB).
G A Gonzalez et al.
Cell, 59(4), 675-680 (1989-11-17)
In this paper, we demonstrate that phosphorylation of CREB at Ser-133 is induced 6-fold in vivo, following treatment of PC12 cells with forskolin. By contrast, no such induction was observed in the kinase A-deficient PC12 line A126-1B2 (A126). Using F9
R P Kwok et al.
Nature, 370(6486), 223-226 (1994-07-21)
The transcription factor CREB binds to a DNA element known as the cAMP-regulated enhancer (CRE). CREB is activated through phosphorylation by protein kinase A (PKA), but precisely how phosphorylation stimulates CREB function is unknown. One model is that phosphorylation may
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