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C7938

Sigma-Aldrich

2-氯-N6-环戊基腺苷

adenosine receptor agonist

同義詞:

CCPA

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About This Item

經驗公式（希爾表示法）:
C15H20ClN5O4
CAS號碼:
37739-05-2
分子量：:
369.80
MDL號碼:
MFCD00078574
分類程式碼代碼:
41106305
PubChem物質ID:
24892583
NACRES:
NA.51

品質等級

200

化驗

≥98% (TLC)

形狀

powder

溶解度

methanol: 19.60-20.40 mg/mL, clear, colorless to faintly yellow

儲存溫度

2-8°C

SMILES 字串

OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(NC4CCCC4)nc(Cl)nc23

InChI

1S/C15H20ClN5O4/c16-15-19-12(18-7-3-1-2-4-7)9-13(20-15)21(6-17-9)14-11(24)10(23)8(5-22)25-14/h6-8,10-11,14,22-24H,1-5H2,(H,18,19,20)/t8-,10-,11-,14-/m1/s1

InChI 密鑰

XSMYYYQVWPZWIZ-IDTAVKCVSA-N

基因資訊

human ... ADORA1(134) , ADORA2A(135) , ADORA2B(136) , ADORA3(140)
rat ... Adora1(29290) , Adora2a(25369) , Adora3(25370)

應用

2-氯-N6-环戊基腺苷（CCPA）是一种具有高选择性的A1腺苷受体激动剂。CCPA通常与其他腺苷受体激动剂和拮抗剂一起使用，以平衡A(1)、A(2A)和A(3)受体的功能。这些药物包括DPCPX（A(1) 受体拮抗剂）、4-(2-[7-氨基-2-(2-呋喃基)[1,2,4]三唑[2,3-α][1,3,5]三嗪-5-基氨基]乙基)苯酚（A(2A)受体拮抗剂）和4-[2-[[6-氨基-9-(N-乙基-β-D-核呋喃核糖酰胺基)-9H-嘌呤-2-基]氨基]乙基]苯丙酸盐酸盐（A(2A) 受体激动剂）和Cl-IB-MECA（A(3)受体激动剂）。

生化／生理作用

具有高选择性的A1腺苷受体激动剂：据报道，A1受体的选择性是A2受体的10,000倍。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

分析證明 (COA)

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N L D Smith et al.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 20(8), O480-O488 (2013-11-28)
Chronic cavitary pulmonary aspergillosis (CCPA) is a progressive lung condition with a 10-30% annual mortality. Although overtly immunocompetent, some immunogenetic defect in patients is likely. To investigate a possible immunogenetic defect in CCPA, we analysed biologically plausible candidate genes in
Iftikhar Ahmad et al.
Scientific reports, 10(1), 364-364 (2020-01-17)
Real world complex networks are indirect representation of complex systems. They grow over time. These networks are fragmented and raucous in practice. An important concern about complex network is link prediction. Link prediction aims to determine the possibility of probable
Romeo Romagnoli et al.
Journal of medicinal chemistry, 51(18), 5875-5879 (2008-08-30)
The synthesis and evaluation of a series of 2-amino-3-(4-chlorobenzoyl)-4-[4-(alkyl/aryl)piperazin-yl]thiophene derivatives as allosteric enhancers of the A 1-adenosine receptor are described. The nature of substituents on the phenyl ring tethered to the piperazine seem to exert a fundamental influence on the
Ruzanna Shkhyan et al.
Journal of molecular medicine (Berlin, Germany), 96(10), 1049-1060 (2018-08-09)
Osteoarthritis (OA), the most common form of arthritis, is characterized by inflammation of joints and cartilage degradation leading to disability, discomfort, severe pain, inflammation, and stiffness of the joint. It has been shown that adenosine, a purine nucleoside composed of
Mary Clare Luca et al.
Clinical hemorheology and microcirculation, 49(1-4), 287-293 (2012-01-05)
Despite decades of research and thousands of experimental publications, acute preconditioning strategies have yet to be implemented in clinical practice. While some have attributed this to a failure of the experimental studies to mimic the clinical environment, others have suggested
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