C7795
氯霉素，大包装
γ-irradiated
同義詞:
D-(−)-苏-2,2-二氯-N-[β-羟基-α-(羟甲基)-β-(4-硝基苯基)乙基]乙酰胺, D-(−)-苏-2-二氯乙酰胺基-1-(4-硝基苯基)-1,3-丙二醇, D-苏-2,2-二氯-N-β[-羟基-α-(羟甲基)-4-硝基苯乙基]乙酰胺, 氯霉素
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About This Item
線性公式:
Cl2CHCONHCH(CH2OH)CH(OH)C6H4NO2
CAS號碼:
分子量：:
323.13
Beilstein:
2225532
EC號碼:
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.31
推薦產品
品質等級
無菌
γ-irradiated
形狀
powder
pKa
~5.5
mp
149-153 °C (lit.)
溶解度
absolute ethanol: 5-20 mg/mL (as a stock solution)
methanol: soluble (as a stock solution)
抗生素活性譜
Gram-negative bacteria
Gram-positive bacteria
mycobacteria
mycoplasma
作用方式
protein synthesis | interferes
儲存溫度
2-8°C
SMILES 字串
OC[C@@H](NC(=O)C(Cl)Cl)[C@H](O)c1ccc(cc1)[N+]([O-])=O
InChI
1S/C11H12Cl2N2O5/c12-10(13)11(18)14-8(5-16)9(17)6-1-3-7(4-2-6)15(19)20/h1-4,8-10,16-17H,5H2,(H,14,18)/t8-,9-/m1/s1
InChI 密鑰
WIIZWVCIJKGZOK-RKDXNWHRSA-N
基因資訊
human ... CYP1A2(1544)
尋找類似的產品？ 前往 產品比較指南
一般說明
Chemical structure: phenicole
應用
Chloramphenicol is a synthetic antibiotic, isolated from strains of Streptomyces venezuelae. It is often used for bacterial selection in molecular biology applications at 10-20 μg/mL and as a selection agent for transformed cells containing chloramphenicol reistance genes.
生化／生理作用
作用机制：氯霉素通过与50S核糖体亚基结合并阻止氨酰基tRNA附着于核糖体来阻断肽基转移酶步骤，从而抑制细菌蛋白质的合成。 它还抑制线粒体和叶绿体蛋白的合成以及（p）ppGpp的核糖体形成，从而抑制rRNA的转录。
耐药性机制：使用氯霉素乙酰转移酶会使产物乙酰化并使其失活。
抗菌谱：这是一种针对革兰氏阳性和革兰氏阴性细菌的广谱抗生素，主要用于眼科和兽医目的。
耐药性机制：使用氯霉素乙酰转移酶会使产物乙酰化并使其失活。
抗菌谱：这是一种针对革兰氏阳性和革兰氏阴性细菌的广谱抗生素，主要用于眼科和兽医目的。
注意
Stock solutions should be stored at 2-8°C and are stable at 37°C for 5 days. Aqueous solutions are neutral and stable over a wide pH range, with 50% hydrolysis occurring after 290 days. Use of a borax buffered solution reduces this number to 14%. Solutions should be protected from light as photochemical decomposition results in a yellowing of the solution. Heating aqueous solutions at 115°C for 30 minutes results in a 10% loss of chloramphenicol.
準備報告
直接用小瓶配制推荐范围内任意浓度的储存液。储存液应在 2-8°C 下保存。在 37°C 下可稳定 5 天。
其他說明
Keep container tightly closed in a dry and well-ventilated place. Light sensitive.
訊號詞
Danger
危險聲明
危險分類
Carc. 2 - Eye Dam. 1 - Repr. 2
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
個人防護裝備
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
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