C6995

Anti-COMT (N-terminal) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

• 同義詞: Anti-Catechol-O-methyltransferase
• 分類程式碼代碼: 12352203
• NACRES: NA.41

屬性

• 生物源: rabbit
• 共軛: unconjugated
• 抗體表格: IgG fraction of antiserum
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 形狀: buffered aqueous solution
• 分子量: antigen ~24 kDa (and ~28 kDa)
• 物種活性: human, rat, mouse
• 技術: western blot: 1:250-1:500 using whole extracts of mouse and rat liver and HEK-293T cells expressing human COMT
• UniProt登錄號: P21964
• 運輸包裝: dry ice
• 儲存溫度: −20°C
• 目標翻譯後修改: unmodified
• 基因資訊: human ... COMT(1312) ; mouse ... Comt1(12846) ; rat ... Comt(24267)

描述

一般說明

The gene Catechol-O-methyltransferase (COMT) is mapped to human chromosome 22q11.2. COMT is also referred to as HEL-S-98n. It is widely expressed in various tissues, including brain, liver, kidney, endometrium and breast.

特異性

The antibody recognizes MB-COMT and S-COMT.

應用

Anti-COMT (N-terminal) antibody produced in rabbit has been used in immunoblotting.

生化／生理作用

Catechol-O-methyltransferase (COMT) is a Mg²⁺-dependent enzyme. COMT catalyzes transfer of methyl groups from S-adenosyl methionine to catecholamines. It is responsible for degradation of catecholamines and thereby results in psychiatric disorders and symptoms. Met/Met genotype individuals can acquire skill in executive function tasks (as multi-unmanned vehicles supervisory control, to a higher level and/or faster than other genotype groups). On the other hand, COMT polymorphism is linked to major depressive disorder and bipolar disorder. The genetic variants of COMT alter neurobehavioral functions that are affected by mercury in adults and might modify the adverse neurobehavioral effects of mercury exposure in children. COMT polymorphism is associated with high risk of premature ovarian insufficiency. COMT single nucleotide polymorphism preoperative humans psychological status and postoperative opioid analgesia efficacy. COMT acts as a tumor supressor gene for colorectal cancer cell lines. Overexpression of COMT supresses pancreatic cancer.

外觀

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)