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About This Item
經驗公式（希爾表示法）:
C9H11ClN2O5
CAS號碼:
分子量：:
262.65
MDL號碼:
分類程式碼代碼:
41106305
PubChem物質ID:
NACRES:
NA.51
推薦產品
品質等級
化驗
≥98% (HPLC)
形狀
powder
溶解度
1 M NH4OH: 20 mg/mL, clear, colorless to faintly yellow
儲存溫度
−20°C
SMILES 字串
OC[C@H]1O[C@H](C[C@@H]1O)N2C=C(Cl)C(=O)NC2=O
InChI
1S/C9H11ClN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s1
InChI 密鑰
NJCXGFKPQSFZIB-RRKCRQDMSA-N
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應用
5-氯-2′-脱氧尿苷已用于：
- 利用动物模型，通过免疫组化分析和双S期标记研究细胞周期动力学
- 使用动物模型分析细胞周期长度
- 标记HEK293T细胞进行分子梳理试验
生化／生理作用
用5-氯-2′-脱氧尿苷(CldU)标记的DNA是分析和量化DNA复制、修复和重组的有效工具。CldU是一种有效的诱变剂、分裂剂和毒物。它被用作胸腺嘧啶类似物，并被发现改变dNTP池，可能导致细胞周期停滞。CldU产生姐妹染色单体交换，但与其他胸腺嘧啶类似物相比，对电离辐射的响应较小。5-氯-2′-脱氧尿苷（CldU，氯脱氧尿苷）用于研究DNA和DNA前体的次氯酸损伤引起碱基错配的潜在可能。在识别DNA复制位点的实验方案中，5-氯-2′-脱氧尿苷(CldU)可掺入DNA以便通过CldU抗体进行后续的免疫荧光成像。氯脱氧尿苷可与其他卤化尿苷，如碘脱氧尿苷(IdU)，共同作为标记底物使用。
訊號詞
Warning
危險分類
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 2
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
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