推薦產品
![聚[(9,9-二正辛基芴基-2,7-二基)-alt-(苯并[2,1,3]噻二唑-4,8-二基)] average Mn ≤25000](/deepweb/assets/sigmaaldrich/product/structures/428/661/1c4ebb98-9d51-48c0-96c7-e556ca425aa4/640/1c4ebb98-9d51-48c0-96c7-e556ca425aa4.png)
品質等級
化驗
≥98% (TLC)
形狀
powder
藥物控制
regulated under CDSA - not available from Sigma-Aldrich Canada
溶解度
2-hydroxypropyl-β-cyclodextrin: insoluble
H2O: insoluble
SMILES 字串
O=C1CN=C(C2=CC=C(Cl)C=C2)C3=CC(Cl)=CC=C3N1C
InChI
1S/C16H12Cl2N2O/c1-20-14-7-6-12(18)8-13(14)16(19-9-15(20)21)10-2-4-11(17)5-3-10/h2-8H,9H2,1H3
InChI 密鑰
PUMYFTJOWAJIKF-UHFFFAOYSA-N
基因資訊
rat ... Tspo(24230)
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應用
4′-氯地西泮在线粒体功能研究中用作转运蛋白配体。此外，也用于研究其对葡萄糖缺失T98G星形胶质细胞的保护作用。
生化／生理作用
4'-氯二氮卓酮 (Ro5-4864) 是线粒体转运蛋白 18 kDa (TSPO) 的强效选择性配体，以前称为外周苯二氮卓类受体 (PBR)。Ro5-4864 不与 GABA (A) 受体结合，缺乏典型的苯二氮卓类效应，但在多项研究中发现其具有神经保护作用。
訊號詞
Warning
危險聲明
危險分類
Acute Tox. 4 Oral
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
A TSPO ligand prevents mitochondrial sterol accumulation and dysfunction during myocardial ischemia-reperfusion in hypercholesterolemic rats
Musman J, et al.
Biochemical Pharmacology, 142, 87-95 (2017)
4?-Chlorodiazepam protects mitochondria in T98G astrocyte cell line from glucose deprivation
Baez E, et al.
Neurotoxicity Research, 32(2), 163-171 (2017)
Federico Da Settimo et al.
Journal of medicinal chemistry, 51(18), 5798-5806 (2008-08-30)
Novel N,N-disubstituted indol-3-ylglyoxylamides (1-56), bearing different combinations of substituents R 1-R 5, were synthesized and evaluated as ligands of the translocator protein (TSPO), the 18 kDa protein representing the minimal functional unit of the "peripheral-type benzodiazepine receptor" (PBR). Most of
Sabrina Taliani et al.
Journal of medicinal chemistry, 50(2), 404-407 (2007-01-19)
Fluorescent ligands for the peripheral-type benzodiazepine receptor (PBR) featuring the 7-nitrobenz-2-oxa-1,3-diazol-4-yl moiety were synthesized, based on N,N-dialkyl-2-phenylindol-3-ylglyoxylamides, a potent, selective class of PBR ligands previously described by us. All the new ligands are moderately to highly potent at the PBR
S Giatti et al.
Neuroscience, 164(2), 520-529 (2009-08-12)
Peripheral neuropathy represents an important complication of diabetes involving a spectrum of structural, functional and biochemical alterations in peripheral nerves. Recent observations obtained in our laboratory have shown that the levels of neuroactive steroids present in the sciatic nerve of
我們的科學家團隊在所有研究領域都有豐富的經驗，包括生命科學、材料科學、化學合成、色譜、分析等.
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