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Key Documents

C4710

Sigma-Aldrich

单克隆抗-细胞周期蛋白A 小鼠抗

clone CY-A1, ascites fluid

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About This Item

MDL號碼:
分類程式碼代碼:
12352203
NACRES:
NA.41

生物源

mouse

共軛

unconjugated

抗體表格

ascites fluid

抗體產品種類

primary antibodies

無性繁殖

CY-A1, monoclonal

分子量

antigen 60 kDa

包含

15 mM sodium azide

物種活性

mouse, human, monkey, bovine

技術

immunocytochemistry: suitable
microarray: suitable
western blot: 1:1,000 using a mouse NIH 3T3 cell extract

同型

IgG2a

UniProt登錄號

運輸包裝

dry ice

儲存溫度

−20°C

目標翻譯後修改

unmodified

基因資訊

human ... CCNA2(890)
mouse ... Ccna2(12428)

一般說明

细胞周期蛋白 A 是 S 期的核蛋白,它与 cdk2 和 cdc2 结合。与细胞周期蛋白 A 特异性反应的单克隆抗体的可用性使得细胞周期蛋白 A 的亚细胞检测和定位,以及细胞周期蛋白水平的相对差异(作为细胞周期阶段的功能)的测量成为可能。

特異性

该抗体识别牛细胞周期蛋白 A 氨基酸 162-433 中存在的表位。未发现与其他细胞周期蛋白(细胞周期蛋白 B、D 或 E)有交叉反应。

免疫原

重组牛细胞周期蛋白 A。

應用

小鼠单克隆抗 Cyclin A 抗体适用于:
  • 免疫细胞化学
  • 微阵列
  • 蛋白质印迹(使用小鼠 NIH 3T3 细胞提取物,1:1,000 稀释)

免責聲明

除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

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儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

nwg

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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Jason M Bodily et al.
Journal of virology, 85(17), 8852-8862 (2011-06-24)
Human papillomaviruses (HPVs) are the causative agents of several important genital and other mucosal cancers. The HPV16 E7 gene encodes a viral oncogene that is necessary for the continued growth of cancer cells, but its role in the normal, differentiation-dependent
Chunyan Weng et al.
International journal of oncology, 42(1), 327-337 (2012-11-09)
Androgen deprivation therapy of prostate cancer with estrogens shows significant cardiovascular side-effects. To develop effective prostate cancer therapeutic agent(s) with minimal cardiovascular side-effects, we compared the effects of various estrogen receptor (ER) ligands on the modulation of dihydrotestosterone (DHT) actions
Matthew Hoare et al.
Nature cell biology, 18(9), 979-992 (2016-08-16)
Senescence, a persistent form of cell-cycle arrest, is often associated with a diverse secretome, which provides complex functionality for senescent cells within the tissue microenvironment. We show that oncogene-induced senescence is accompanied by a dynamic fluctuation of NOTCH1 activity, which
Andres Dekanty et al.
The Journal of biological chemistry, 281(10), 6136-6143 (2005-11-18)
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