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Merck
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重要文件

C4650

Sigma-Aldrich

考来烯胺树脂

同義詞:

Dowex 1X2 Cl--形态, 消胆胺

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About This Item

CAS號碼:
EC號碼:
MDL號碼:
分類程式碼代碼:
23151817
NACRES:
NA.56

形狀

powder

品質等級

技術

activity assay: suitable

基質

polystyrene/divinylbenzene

pH值

4—6

容量

~1.0 meq/g(dry)

應用

消胆胺树脂可用于:
  • 作为膳食补充剂,研究小鼠胆汁酸池大小和粪便胆汁酸排出量
  • 改变胆汁酸(BA)水平,研究其对野生型(WT)、成纤维生长因子15(Fgf15)−/−和Fgf15转基因(TG)小鼠肝纤维化发展的影响
  • 参与体外消化过程,研究其结合胆汁酸(BA)的能力

消胆胺树脂用于蛋白质层析、离子交换层析和阴离子交换介质。考来烯胺已被用于研究缓解胆囊切除术后腹泻、管理顽固性胆汁淤积性瘙痒和肥胖。

生化/生理作用

消胆胺是一种阳离子交换树脂。这种树脂可作为胆汁酸螯合剂,所含氯离子与小肠腔胆汁酸交换后,螯合的胆汁酸从粪便排出,使血清胆汁酸水平下降。消胆胺也用于治疗原发性高胆固醇血症。这种树脂可使低密度脂(LDL)胆固醇剂量依赖性减少。降低冠心病风险。

其他說明

交联聚苯乙烯上的季铵盐官能团

法律資訊

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 2

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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