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一般說明
肌酸激酶(CK)由 M 和 B 亚基组成,是一种二聚合分子。它是一种 CK 同工酶。这种酶主要存在于心肌中。
應用
来自人心的肌酸激酶 MB 已用于:
- 作为急性心肌梗死的诊断标志物。
- 识别血液和心脏标志物的重叠吸收峰。
- 研究HIV-1感染的潜在治疗药物二氧戊环鸟苷(DXG)的体内磷酸化途径。
生化/生理作用
肌酸激酶(CK)可催化从磷酸肌酸形成肌酸酐。该酶与冠状动脉性能相关。CK-MB 血清水平升高是心肌细胞损伤的主要指标,它被视作心肌梗死诊断的“金标准”。心肌肌钙蛋白 I(cTnI)或心肌肌钙蛋白 I 的水平也与 CK-MB 水平升高相关。慢性肾衰竭时 CK-MB 的水平也可能升高。
成分
溶于 5 mM 琥珀酸钠、10 mM 氯化钠、1 mM EDTA、5 mMβ-巯基乙醇,50% 甘油,pH 7.0。
儲存類別代碼
10 - Combustible liquids
水污染物質分類(WGK)
WGK 1
閃點(°F)
Not applicable
閃點(°C)
Not applicable
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We evaluated the short- and long-term clinical outcomes of 326 consecutive patients with chronic renal failure, not on dialysis, who had creatine kinase (CK)-myocardial band (MB) fraction elevation after successful percutaneous coronary intervention in a native coronary artery. Based on
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