一般說明
Bone morphogenetic proteins (BMPs) are the members of the TGF-β superfamily and are identified as the critical factors for formation of bone and cartilage. Apart from this BMPs have immune regulatory functions. The cellular effects of BMPs are mediated by a heteromeric complex composed of type I and type II receptors. BMP-6 regulates both T cell and B cell-mediated immunity. It acts through Smad and p38 pathway to induce the expression of IL-6. Additionally, it induces the expression of iNOS by macrophages through the activation of NF-κB and STAT pathways. BMP-6 is a stimulator of differentiation of liver, bone, neuronal tissue and embryonic kidney and urinary systems. Studies also indicate that BMP-6 is important in the regulation of liver hormone, hepcidin, expression that is important to maintain systemic iron balance
Monoclonal Anti-Bone Morphogenetic Protein 6 recognizes human BMP-6. The antibody shows no cross-reactivity with recombinant human (rh) BMP-2, rhBMP-4, rhBMP-5, and rhBMP-7.
Monoclonal Anti-Bone Morphogenetic Protein 6 recognizes human BMP-6. The antibody shows no cross-reactivity with recombinant human (rh) BMP-2, rhBMP-4, rhBMP-5, and rhBMP-7.
免疫原
recombinant human BMP-6.
應用
Anti-Bone Morphogenetic Protein 6 antibody may be used for immunoblotting at a working concentration of 1.0-2.0 μg/ml. For capture ELISA a concentration of 4 μg/ml is recommemnded. The antibody is also suitable for neutralization reactions.
外觀
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.
準備報告
Purified using protein G.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
13 - Non Combustible Solids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
Seok J Kwon et al.
Immunology, 128(1 Suppl), e758-e765 (2009-09-25)
Bone morphogenetic proteins (BMPs) are members of the transforming growth factor-beta (TGF-beta) superfamily. In the present study, we investigated the effect of BMPs on the production of inducible nitric oxide synthase (iNOS) in the murine macrophage cell line, RAW 264.7
Elena Corradini et al.
Hepatology (Baltimore, Md.), 54(1), 273-284 (2011-04-14)
The bone morphogenetic protein 6 (BMP6)-SMAD signaling pathway is a central regulator of hepcidin expression and systemic iron balance. However, the molecular mechanisms by which iron is sensed to regulate BMP6-SMAD signaling and hepcidin expression are unknown. Here we examined
Geun Taek Lee et al.
The Journal of biological chemistry, 285(50), 39401-39408 (2010-10-05)
Unlike the prototype transforming growth factor-β (TGF-β), bone morphogenetic protein-6 (BMP-6) activates macrophages. Here, we report that BMP-6 induces the expression of IL-6 in macrophages. Using overexpression and knockdown experiments, we demonstrate that BMP receptor type II and activin-like kinase-2
Jun Hyuk Hong et al.
Immunology, 128(1 Suppl), e442-e450 (2009-02-05)
Bone morphogenetic proteins (BMPs) are members of the transforming growth factor (TGF)-beta superfamily which regulates bone formation, haematopoiesis and development. While TGF-beta is known to be a negative regulator of the immune system, the effect of BMPs on the immune
Kohei Miyazono et al.
Cytokine & growth factor reviews, 16(3), 251-263 (2005-05-06)
Bone morphogenetic proteins (BMPs), members of the transforming growth factor-beta (TGF-beta) superfamily, bind to two different serine/threonine kinase receptors, and mediate their signals through Smad-dependent and Smad-independent pathways. Receptor regulated-Smad (R-Smad) proteins specific for the BMP pathways interact with various
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