跳轉至內容
Merck
全部照片(1)

Key Documents

更多文件

B150

Sigma-Aldrich

BQ-123

≥99%, sodium salt, lyophilized powder

同義詞:

BQ123, Cyclo(D-Trp-D-Asp-Pro-D-Val-Leu)

登入查看組織和合約定價
全部照片(1)

About This Item

經驗公式（希爾表示法）:
C31H41N6O7 Na
CAS號碼:
136553-81-6
分子量：:
632.68
MDL號碼:
MFCD00133204
分類程式碼代碼:
12352200
PubChem物質ID:
24891595
NACRES:
NA.32

品質等級

200

化驗

≥99%

形狀

lyophilized powder

儲存溫度

−20°C

SMILES 字串

[H][C@@]12CCCN1C(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC2=O)C(C)C

InChI

1S/C31H42N6O7/c1-16(2)12-21-27(40)33-22(13-18-15-32-20-9-6-5-8-19(18)20)28(41)35-23(14-25(38)39)31(44)37-11-7-10-24(37)29(42)36-26(17(3)4)30(43)34-21/h5-6,8-9,15-17,21-24,26,32H,7,10-14H2,1-4H3,(H,33,40)(H,34,43)(H,35,41)(H,36,42)(H,38,39)/t21-,22+,23+,24-,26+/m0/s1

InChI 密鑰

VYCMAAOURFJIHD-PJNXIOHISA-N

基因資訊

human ... EDNRA(1909) , EDNRB(1910)
rat ... Ednra(24326) , Ednrb(50672)

尋找類似的產品？ 前往 產品比較指南

Amino Acid Sequence

cyclo-Asp-Pro-Val-Leu-Trp

應用

BQ-123已用作选择性内皮素-A受体拮抗剂，研究其对肿瘤坏死因子α(TNFα)诱导的人气道平滑肌细胞(HASMC)增殖的影响。作为内皮素-A受体拮抗剂，它还用于研究其对TNFα诱导的粒细胞-巨噬细胞集落刺激因子(GM-CSF) 表达的影响。

生化／生理作用

BQ-123是一种内皮素(Et)受体拮抗剂，对内皮素A(ETA)受体敏感。它是一种环五肽。
选择性ETA内皮素受体拮抗剂。

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

分析證明 (COA)

輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。

已經擁有該產品？

您可以在文件庫中找到最近購買的產品相關文件。

存取文件庫

T D Warner et al.
British journal of pharmacology, 112(1), 207-213 (1994-05-01)
1. Endothelin-1 binds almost irreversibly to its receptors and causes prolonged vasoconstrictions. Here we have studied the reversal of established responses to ET-1 in vivo and in vitro by BQ-123, an ETA receptor-selective antagonist, and/or PD 145065, an ETA/ETB receptor
F Cosentino et al.
Journal of cardiovascular pharmacology, 22 Suppl 8, S332-S335 (1993-01-01)
The present study was designed to determine whether an endothelinA (ETA)-receptor antagonist BQ-123 (cyclo[Dtrp, Dasp, pro-D-Val-Leu]) or an ET-converting enzyme inhibitor phosphoramidon may prevent development of cerebral vasospasm after subarachnoid hemorrhage (SAH). A "double hemorrhage" canine model of the disease
M Clozel et al.
Life sciences, 52(9), 825-834 (1993-01-01)
The aim of this study was to evaluate the role of endothelin and endothelin ETA receptor in the early cerebral vasoconstriction following subarachnoid hemorrhage (SAH) in the rat. SAH induced by injection of autologous blood in the cisterna magna reduced
Junichi Takano et al.
Drug metabolism and disposition: the biological fate of chemicals, 46(5), 652-657 (2018-01-20)
Among organic anion transporting polypeptide (Oatp) family transporters expressed in the rodent liver, such as Oatp1a1, Oatp1a4, Oatp1b2, and Oatp2b1, Oatp1a4 has a unique character to recognize neutral cardiac glycosides as a substrate in addition to organic anions. The relative
Masahiro Tonari et al.
Investigative ophthalmology & visual science, 53(7), 3490-3500 (2012-05-09)
The endothelins (ETs) cause reactive astrogliosis, which involves neuroinflammation and neurodegeneration in the central nervous system. The purpose of this study was to determine whether blocking the ET signals will protect retinal ganglion cells (RGCs) from optic nerve injury. We
查看所有相關論文

我們的科學家團隊在所有研究領域都有豐富的經驗，包括生命科學、材料科學、化學合成、色譜、分析等.

聯絡技術服務