推薦產品
生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
82 kDa
物種活性
rabbit, horse, guinea pig, rat, human, bovine, dog, mouse
濃度
0.5 mg - 1 mg/mL
技術
western blot: suitable
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... SIRT1(23411)
一般說明
Sirtuin（沉默交配型信息调节2同源物）1（ 酿酒酵母）（SIRT1）是NAD（+）依赖性蛋白脱乙酰酶SIRT家族的成员，参与调节涉及能量代谢的基因的核转录。 SIRT1提供了细胞能量状态感知（NAD（+）状态）与能量稳态调节之间的联系。SIRT1参与代谢、细胞分化和衰老、应激反应和癌症的调节。
兔多克隆抗SIRT1抗体可与鸡，人，小鼠，大鼠，犬和猪的sirtuin-1酶反应。
免疫原
靶向人SIRT1 N末端区域的合成肽
應用
兔多克隆抗SIRT1抗体用于标记sirtuin-1，以通过免疫细胞化学和免疫组化（IHC）技术进行检测和定量。它被用作探针来确定sirtuin-1在核转录控制和蛋白脱乙酰化水平上NAD（+）状态依赖性能量稳态中的存在和作用。
兔抗SIRT1抗体可在0.5 μg/ml浓度下用于蛋白质印迹应用。
生化／生理作用
SIRT1是sirtuin蛋白家族的成员，与酵母Sir2蛋白同源。sirtuin家族的成员以sirtuin核心域为特征，分为四类。人类sirtuins的功能尚未确定。
序列
合成肽位于以下区域内： PETIPPPELDDMTLWQIVINILSEPPKRKKRKDINTIEDAVKLLQECKKI
外觀
本品为溶于1x PBS缓冲液的纯化抗体，含 0.09% (w/v) 叠氮化钠和2%蔗糖。
免責聲明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Knut H Lauritzen et al.
Neurobiology of aging, 48, 34-47 (2016-09-18)
Mitochondrial genome maintenance plays a central role in preserving brain health. We previously demonstrated accumulation of mitochondrial DNA damage and severe neurodegeneration in transgenic mice inducibly expressing a mutated mitochondrial DNA repair enzyme (mutUNG1) selectively in forebrain neurons. Here, we
Éverton Lopes Vogt et al.
International journal of environmental research and public health, 18(14) (2021-07-25)
Introduction and objectives: Obesity represents a major global public health problem. Its etiology is multifactorial and includes poor dietary habits, such as hypercaloric and hyperlipidic diets (HFDs), physical inactivity, and genetic factors. Regular exercise is, per se, a tool for
Hongyi Zhang et al.
International journal of oncology, 45(5), 2143-2152 (2014-08-15)
MicroRNA (miRNA or miR) inhibition of oncogenic related pathways has been shown to be a promising therapeutic approach for cancer. SIRT1 might be a promoter factor on tumorigenesis of hepatocellular carcinoma (HCC). However, the mechanism is unknown. We investigated whether
Yan Li et al.
International journal of molecular medicine, 41(6), 3517-3526 (2018-03-14)
Mitochondrial dynamics have critical roles in aging, and their impairment represents a prominent risk factor for myocardial dysfunction. Mitochondrial deacetylase sirtuin (SIRT)3 contributes greatly to the prevention of redox stress and cell aging. The present study explored the role of SIRT3
Liang Lv et al.
Medical oncology (Northwood, London, England), 31(6), 965-965 (2014-05-13)
Sirtuin 1 (SIRT1) has been reported to have diverse roles in various biological processes through deacetylation of histone and nonhistone proteins. However, the correlations between SIRT1 protein expression, clinicopathological parameters, and survival of colorectal cancer patients remain unclear. SIRT1 protein
我們的科學家團隊在所有研究領域都有豐富的經驗，包括生命科學、材料科學、化學合成、色譜、分析等.
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