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A8986

Sigma-Aldrich

阿来西定 二盐酸盐

≥95% (HPLC)

同義詞:

1,1′-六亚甲基-双(5-[2-乙基己基]双胍)

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About This Item

經驗公式(希爾表示法):
C26H56N10 · 2HCl
CAS號碼:
分子量::
581.71
EC號碼:
MDL號碼:
分類程式碼代碼:
12352200
PubChem物質ID:
NACRES:
NA.77

化驗

≥95% (HPLC)

形狀

powder

儲存條件

desiccated

顏色

white to off-white

溶解度

DMSO: ≥10 mg/mL

儲存溫度

−20°C

SMILES 字串

Cl.Cl.CCCCC(CC)CNC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NCC(CC)CCCC

InChI

1S/C26H56N10.2ClH/c1-5-9-15-21(7-3)19-33-25(29)35-23(27)31-17-13-11-12-14-18-32-24(28)36-26(30)34-20-22(8-4)16-10-6-2;;/h21-22H,5-20H2,1-4H3,(H5,27,29,31,33,35)(H5,28,30,32,34,36);2*1H

InChI 密鑰

BRJJFBHTDVWTCJ-UHFFFAOYSA-N

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應用

己联双辛胍二盐酸盐已:
  • 用作一种防腐剂,研究其在唾液微生物膜中的抗菌活性
  • 用作一种定位于线粒体1 (PTPMT1)特异性抑制剂的蛋白酪氨酸磷酸酶,以研究其对CD8+ T细胞剩余呼吸能力和活力的影响
  • 用作PTPMT1抑制剂,研究其在人巨细胞病毒(HCMV)感染的人包皮成纤维细胞(HFF)中复制的抗病毒作用

生化/生理作用

己联双辛胍二盐酸盐是一种双胍化合物。它已经被用于头颈癌的治疗。己联双辛胍二盐酸盐对几种真菌也表现出抗菌膜和抗真菌活性。由于其抗癌活性,可引起哺乳动物细胞线粒体凋亡。己联双辛胍二盐酸盐是口腔消毒剂和隐形眼镜溶液的组分。
己联双辛胍二盐酸盐是一种有效的选择性PTPMT1(线粒体蛋白酪氨酸磷酸酶1)抑制剂。己联双辛胍能够增加离体大鼠胰岛的胰岛素分泌。

特點和優勢

《受体分类和信号转导》手册的 磷蛋白磷酸酶(酪氨酸) 页面有该化合物的介绍。想要浏览手册的其他页面, 请单击此处

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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J A Chawner et al.
The Journal of applied bacteriology, 66(3), 253-258 (1989-03-01)
Strains of Providencia stuartii with demonstrated resistance towards chlorhexidine did not show such resistance towards either of the related biguanide antiseptics, alexidine or vantocil. Alexidine promoted a significantly faster alteration in the permeability of Escherichia coli cell membranes towards various
Kenneth W Yip et al.
Molecular cancer therapeutics, 5(9), 2234-2240 (2006-09-21)
Despite advances in surgery, radiation, and chemotherapy, novel therapeutics are needed for head and neck cancer treatment. The objective of this current study was to evaluate alexidine dihydrochloride as a novel compound lead for head and neck cancers. Using a
Cationic antiseptics: diversity of action under a common epithet.
P Gilbert et al.
Journal of applied microbiology, 99(4), 703-715 (2005-09-16)
Hyun-Shik Kim et al.
International journal of oral science, 5(1), 26-31 (2013-03-16)
A previous study demonstrated that alexidine has greater affinity for the major virulence factors of bacteria than chlorhexidine. The aim of this study was to compare the antimicrobial activity of 1% alexidine with that of 2% chlorhexidine using Enterococcus faecalis-infected
Sophia R Schwarz et al.
Clinical oral investigations, 25(5), 2939-2950 (2020-10-10)
The aims of this study were to investigate the antimicrobial efficacy of antiseptics in saliva-derived microcosm biofilms, and to examine phenotypic adaption of bacteria upon repeated exposure to sub-inhibitory antiseptic concentrations. Saliva-derived biofilms were formed mimicking caries- or gingivitis-associated conditions

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