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A8486

Sigma-Aldrich

N-（对甲酰基肉桂酰）邻氨基苯甲酸

≥98% (HPLC)

同義詞:

2-[[1-氧代-3-（4-戊基苯基）-2-丁-1-基]氨基]-苯甲酸, ACA, N-（4-戊基肉桂酰胺）邻氨基苯甲酸

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About This Item

經驗公式（希爾表示法）:
C21H23NO3
CAS號碼:
99196-74-4
分子量：:
337.41
MDL號碼:
MFCD00211365
分類程式碼代碼:
12352106
PubChem物質ID:
329770958
NACRES:
NA.77

化驗

≥98% (HPLC)

形狀

powder

顏色

white to off-white

溶解度

DMSO: ≥20 mg/mL

儲存溫度

room temp

SMILES 字串

CCCCCc1ccc(\C=C\C(=O)Nc2ccccc2C(O)=O)cc1

InChI

1S/C21H23NO3/c1-2-3-4-7-16-10-12-17(13-11-16)14-15-20(23)22-19-9-6-5-8-18(19)21(24)25/h5-6,8-15H,2-4,7H2,1H3,(H,22,23)(H,24,25)/b15-14+

InChI 密鑰

GAMRBCZMOOMBSQ-CCEZHUSRSA-N

一般說明

氨基苯甲酸 (ACA) 是一种广谱磷脂酶 A2 抑制剂，可阻断瞬时受体电位 (TRP) 通道。抑制心室肌细胞中钙激活的氯化物电流。ACA 调节多种离子通道。

應用

N -（ p -戊基肉桂酰）邻氨基苯甲酸已被用作瞬时受体电位阳离子通道亚家族 M 成员 2 (TRPM2) 抑制剂，研究其在调节活性氧 (ROS) 产生中的作用。
N-（p-氨酰肉桂酰）邻氨基苯甲酸是一种广谱 PLA2 抑制剂和 TRP 通道阻滞剂。N-（p-戊酰肉桂酰）邻氨基苯甲酸已被用于研究多巴胺能 SNc 神经元中 TRPM2 通道的功能表达。

生化／生理作用

广谱磷脂酶 A2 (PLA2) 抑制剂和 TRP 通道阻断剂。

特點和優勢

该化合物在受体分类和信号转导手册的磷脂酶A2 页面上有重点介绍。想要浏览手册的其他页面， 请单击此处。

象形圖

Environment
GHS09

訊號詞

Warning

危險聲明

H410

防範說明

P273 - P391 - P501

危險分類

Aquatic Acute 1 - Aquatic Chronic 1

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

分析證明 (COA)

輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。

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Phospholipase A2

Phospholipase A2 (PLA2) designates a class of enzymes that hydrolyze the sn-2 ester of glycerophospholipids to produce a fatty acid and a lysophospholipid. It has become clear that some of these enzymes liberate arachidonic acid in mammalian cells for the biosynthesis of eicosanoids, and thus there has been considerable interest in developing PLA2 inhibitors. Based on amino acid sequences, there are now more than 12 distinct groups of mammalian PLA2s, as well as many non-mammalian forms, all of which have been classified into 14 distinct groups with many subgroups.

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