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A4393

Sigma-Aldrich

R-(−)-阿朴吗啡 盐酸盐 半水合物

calcined, ≥98.5% (with NaOH, titration)

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About This Item

線性公式:
C17H17NO2 · HCl · 1/2H2O
CAS號碼:
41372-20-7
分子量：:
312.79
EC號碼:
206-243-0
MDL號碼:
MFCD00150904
分類程式碼代碼:
12352210
PubChem物質ID:
24278821
NACRES:
NA.77

品質等級

200

化驗

≥98.5% (with NaOH, titration)

形狀

calcined
 (Powder to Crystalline Powder)

儲存條件

protect from light
under inert gas

顏色

white to gray

mp

285-287 °C (lit.)

溶解度

H2O: ~10 mg/mL, clear, yellow-green

SMILES 字串

Cl[H].Cl[H].[H]O[H].[H][C@]12Cc3ccc(O)c(O)c3-c4cccc(CCN1C)c24.[H][C@]56Cc7ccc(O)c(O)c7-c8cccc(CCN5C)c68

InChI

1S/2C17H17NO2.2ClH.H2O/c2*1-18-8-7-10-3-2-4-12-15(10)13(18)9-11-5-6-14(19)17(20)16(11)12;;;/h2*2-6,13,19-20H,7-9H2,1H3;2*1H;1H2/t2*13-;;;/m11.../s1

InChI 密鑰

CXWQXGNFZLHLHQ-DPFCLETOSA-N

基因資訊

human ... DRD1(1812) , DRD2(1813) , DRD3(1814) , DRD4(1815) , DRD5(1816)

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應用

R-(-)-阿朴吗啡盐酸半水化合物已用作多巴胺受体激动剂，研究对帕金森症大鼠旋转行为的影响。

生化／生理作用

R-(−)-阿朴吗啡是一种非选择性的D1和D2多巴胺受体激动剂。它对帕金森病和男性勃起功能障碍有治疗作用。R-(−)-阿朴吗啡还具有神经保护、自由基清除和催吐作用。阿朴吗啡可刺激大脑的化学感受器触发区。它会刺激大脑中的化学感受器触发区。

象形圖

Skull and crossbones
GHS06

訊號詞

Danger

危險聲明

H301

防範說明

P301 + P310

危險分類

Acute Tox. 3 Oral

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

分析證明 (COA)

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