推薦產品
生物源
Pseudomonas aeruginosa
品質等級
形狀
lyophilized powder
成份
Protein, ≥65% Lowry
濃度
≥65.0% (Lowry)
技術
toxicology assay: suitable
溶解度
water: soluble 1—1.1 mg/mL, clear, blue (light blue to blue)
UniProt登錄號
儲存溫度
−20°C
基因資訊
Pseudomonas aeruginosa ... AZU(878046)
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一般說明
Research area: Apoptosis. Azurinis a periplasmic protein and is a homotetramer.
應用
天青素可用于：
- 骨肉瘤细胞系的细胞毒性和细胞活力研究
- 相互作用研究中氮化硅悬臂的功能化
- 氧化硅和云母的金表面和绝缘的功能化氧化物表面的涂层
生化／生理作用
天青素是铜氧还蛋白家族中的金属蛋白。它比正常细胞优先进入癌细胞并诱导细胞凋亡。Azurin 与 ephrinB2 结构相似，并且实际上结合了 ephrin 受体酪氨酸激酶 EphB2 来启动参与癌症发展的细胞信号传导。天青素抑制 EphB2 酪氨酸残基的自磷酸化，干扰上游细胞信号传导并有助于抑制癌细胞生长。
Azurin acts as an electron donor for nitrite reductase in bacterial denitrification process. It exhibits anticancer activity as it hampers various independent signaling pathways associated with cancer progression. It binds to tumor suppressor protein p53 and induces cancer cell apoptosis or stalls cancer cell growth. Azurin disrupts angiogenesis by reducing the activity of VEGFR-2tyrosine kinase thereby inhibiting tumor growth. It has been observed to show cytotoxicity in human breast cancer cells and human melanoma cells.
外觀
含有醋酸铵缓冲盐的冻干粉末。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
Yunlei Zhang et al.
Applied and environmental microbiology, 78(21), 7603-7610 (2012-08-28)
Many studies have demonstrated that intravenously administered bacteria can target and proliferate in solid tumors and then quickly be released from other organs. Here, we employed the tumor-targeting property of Escherichia coli Nissle 1917 to inhibit mouse B16 melanoma and
Krzysztof Kazimierczuk et al.
Journal of magnetic resonance (San Diego, Calif. : 1997), 223, 1-10 (2012-09-11)
The resolution of multidimensional NMR spectra can be severely limited when regular sampling based on the Nyquist-Shannon theorem is used. The theorem binds the sampling rate with a bandwidth of a sampled signal and thus implicitly creates a dependence between
Bacterial redox protein azurin induce apoptosis in human osteosarcoma U2OS cells
Yang DS, et al.
Pharmacological Research, 52(5), 413-421 (2005)
Ajay Kumar Yagati et al.
Biosensors & bioelectronics, 40(1), 283-290 (2012-08-14)
We developed a nanoscale memory device consisting of signal-responsive biomaterial, which is capable of switching physical properties (such as electrical/electrochemical, optical, and magnetic) upon application of appropriate electrical signals to perform memory switching. Here, we propose a highly robust surface-confined
Daniel Raimunda et al.
Metallomics : integrated biometal science, 5(2), 144-151 (2013-01-29)
Pseudomonas aeruginosa, an opportunistic pathogen, has two transmembrane Cu(+) transport ATPases, CopA1 and CopA2. Both proteins export cytoplasmic Cu(+) into the periplasm and mutation of either gene leads to attenuation of virulence. CopA1 is required for maintaining cytoplasmic copper levels
我們的科學家團隊在所有研究領域都有豐富的經驗，包括生命科學、材料科學、化學合成、色譜、分析等.
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