A1594

Anti-Activin A antibody produced in goat

affinity isolated antibody, lyophilized powder

• 同義詞: Activin A Antibody, Anti-Activin A antibody produced in goat
• MDL號碼: MFCD02095789
• 分類程式碼代碼: 51111800
• NACRES: NA.41
• 共軛: unconjugated
• application: ELISA; IHC (p); Neutral; WB
• 無性繁殖: polyclonal
• 物種活性: human
• citations: 6
• 技術: ELISA: suitable; immunohistochemistry (formalin-fixed, paraffin-embedded sections): 5-15 μg/mL; neutralization: suitable; western blot: 0.1 μg/mL

屬性

• 生物源: goat
• 品質等級: 100
• 重組細胞: expressed in goat
• 共軛: unconjugated
• 抗體表格: affinity isolated antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 形狀: lyophilized powder
• 物種活性: human
• 技術: ELISA: suitable; immunohistochemistry (formalin-fixed, paraffin-embedded sections): 5-15 μg/mL; neutralization: suitable; western blot: 0.1 μg/mL
• UniProt登錄號: P08476
• 應用: research pathology
• 儲存溫度: −20°C
• 目標翻譯後修改: unmodified
• 基因資訊: human ... INHBA(3624)

描述

一般說明

Activin A protein belongs to the transforming growth factor-β (TGF-β) superfamily. This protein is a homodimer of two βA subunits. The INHBA gene is located on the human chromosome at 7p14.1.

免疫原

recombinant human activin A expressed in CHO cells.

應用

Anti-Activin A antibody can be used for immunohistochemistry (5-15 μg/mL), western blot (0.1 μg/mL) and neutralization assays.

Anti-Activin A antibody produced in goat has been used in immunohistochemical staining.

生化／生理作用

Activin A protein is involved in regulating developmental genes such as cell cycle regulators like p21, p15, paired box protein (Pax-6) and hormones like follicle-stimulating hormone (FSH). This protein also regulates its antagonist like follistatin and mothers against decapentaplegic homolog 7 (SMAD7). Activin A protein binds to the type 1 receptor activin receptor type 1B (ActR1B) and type 2 receptor activin receptor 2A and 2B (ActRIIA and ActRIIB). Activin A gene is highly expressed in esophageal carcinoma, lung adenocarcinoma, and malignant pleural mesothelioma (MPM). This gene expression is decreased during breast cancer, neuroblastoma, and hepatocellular carcinoma (HCC). Activins bind to the type II Activin receptor triggering phosphorylation of type I Activin receptor (ALK4) and activation of downstream pathways such as proliferation and apoptosis. Activin acts as a tumor suppressor by reducing cell proliferation in cancer cells.

外觀

Lyophilized from 0.2 μm-filtered solution in phosphate buffered saline containing carbohydrates.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable