A1341

N-Acetyl-Glu-Ser-Met-Asp-al

≥90% (HPLC), powder

• 同義詞: Ac-ESMD-CHO
• 經驗公式（希爾表示法）: C₁₉H₃₀N₄O₁₀S
• CAS號碼: 191338-87-1
• 分子量：: 506.53
• MDL號碼: MFCD01318859
• 分類程式碼代碼: 12352202
• PubChem物質ID: 329770361
• NACRES: NA.77

屬性

• 化驗: ≥90% (HPLC)
• 形狀: powder
• 顏色: white
• 溶解度: H₂O: 1 mg/mL
• 儲存溫度: −20°C
• SMILES 字串: CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(C)=O)C(=O)N[C@@H](CC(O)=O)C=O
• InChI: 1S/C19H30N4O10S/c1-10(26)20-12(3-4-15(27)28)18(32)23-14(9-25)19(33)22-13(5-6-34-2)17(31)21-11(8-24)7-16(29)30/h8,11-14,25H,3-7,9H2,1-2H3,(H,20,26)(H,21,31)(H,22,33)(H,23,32)(H,27,28)(H,29,30)/t11-,12-,13-,14-/m0/s1
• InChI 密鑰: TVTYMGFOGZRIHG-XUXIUFHCSA-N

描述

一般說明

N-Acetyl-Glu-Ser-Met-Asp-aldehyde (Ac-ESMD-CHO) is a tetrapeptide analog that act to inhibit the activity of caspase-3 and caspase-7 proteins, which are involved in apoptosis. Ac-ESMD-CHO has been shown to block formation of the caspase-3 p17 and p12 subunits, induce accumulation of the p20 precursor peptide, inhibit 25-hydroxycholesterol-induced apoptosis in rat Sertoli cells and also to bind caspase-7.

生化／生理作用

In the caspase-3 precursor, procaspase-3, the ESMD amino acid sequence has been identified as a cleavage site for producing the p17 and p12 subunits of mature caspase 3; Ac-ESMD-CHO has been shown to inhibit the protease that cleaves procaspase-3 at this site. Ac-ESMD-CHO binds caspase-7 and inhibits with a K_i of approximately 1300 nM, which makes it a weaker inhibitor than other inhibitor tetrapeptide analogs.

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Gloves, type N95 (US)