A0257

阿托品 硫酸盐 一水合物

≥97% (TLC), crystalline, cholinergic receptor antagonist

• 同義詞: (8-甲基-8-氮杂双环[3.2.1]辛-3-基) edno-(+/-)-α-(羟甲基)苯乙酸酯, 龙葵碱
• 線性公式: (C₁₇H₂₃NO₃)₂ · H₂SO₄ · H₂O
• CAS號碼: 5908-99-6
• 分子量：: 694.83
• Beilstein: 6109275
• EC號碼: 200-235-0
• MDL號碼: MFCD00074815
• 分類程式碼代碼: 12352210
• PubChem物質ID: 57653815
• NACRES: NA.32

屬性

• 產品名稱: 阿托品 硫酸盐 一水合物, ≥97% (TLC), crystalline
• 品質等級: 200
• 化驗: ≥97% (TLC)
• 形狀: crystalline
• 顏色: white
• mp: 189-192 °C (A) (lit.)
• 溶解度: H₂O: 2.5 g/mL (stable for several days at 4 °C.); ethanol: 200 mg/mL (stable for several days at 4 °C.); glycerol: 400 mg/mL (stable for several days at 4 °C.)
• SMILES 字串: O.OS(O)(=O)=O.CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)C(CO)c3ccccc3.CN4[C@H]5CC[C@@H]4C[C@@H](C5)OC(=O)C(CO)c6ccccc6
• InChI: 1S/2C17H23NO3.H2O4S.H2O/c2*1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12;1-5(2,3)4;/h2*2-6,13-16,19H,7-11H2,1H3;(H2,1,2,3,4);1H2/t2*13-,14+,15+,16?;;
• InChI 密鑰: JPKKQJKQTPNWTR-CHYDPLAESA-N
• 基因資訊: human ... CHRM1(1128) , CHRM2(1129) , CHRM3(1131) , CHRM4(1132) , CHRM5(1133)

描述

一般說明

Atropine is isolated from Atropa belladonna, Datura stramonium and Mandragora officinarum. It is a tertiary amine, which acts as a cholinergic receptor antagonist.

應用

Atropine sulfate salt hydrate has been used:

• to assay specific binding of high-affinity 3-quinuclidinyl benzilate-3H ([³H]QNB) to the muscarinic acetylcholine receptor (mAChR)
• to block the recovery phase of the aldicarb (Ald) response
• as an analyte for liquid chromatography with tandem mass spectrometry (LC-MS/MS)
• as a mAChR antagonist to block acetylcholine receptor

生化／生理作用

位于中枢和外周毒蕈碱型乙酰胆碱受体处的竞争性非选择性拮抗剂。

安全資訊

• 象形圖: GHS06
• 訊號詞: Danger
• 危險聲明: H300 + H330
• 防範說明: P260 - P264 - P271 - P284 - P304 + P340 + P310 - P403 + P233
• 危險分類: Acute Tox. 2 Inhalation - Acute Tox. 2 Oral
• 儲存類別代碼: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• 水污染物質分類（WGK）: WGK 3
• 個人防護裝備: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges