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Merck
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Key Documents

A0189

Sigma-Aldrich

Amyloid β Protein Fragment 1-38

≥95% (HPLC), powder

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About This Item

經驗公式(希爾表示法):
C184H277N51O56S
CAS號碼:
分子量::
4131.54
MDL號碼:
分類程式碼代碼:
12352202
NACRES:
NA.77

品質等級

化驗

≥95% (HPLC)

形狀

powder

顏色

white

溶解度

H2O: 1 mg/mL

UniProt登錄號

儲存溫度

−20°C

基因資訊

human ... APP(351)

Amino Acid Sequence

Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly

生化/生理作用

β-Amyloid peptide that forms cross-β-sheet fibrils of 70-90 Å diameter with similar antigenicity as those found in Alzheimer′s disease.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


分析證明 (COA)

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M P Mattson et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 12(2), 376-389 (1992-02-01)
In Alzheimer's disease (AD), abnormal accumulations of beta-amyloid are present in the brain and degenerating neurons exhibit cytoskeletal aberrations (neurofibrillary tangles). Roles for beta-amyloid in the neuronal degeneration of AD have been suggested based on recent data obtained in rodent
P E Gottschall
Neuroreport, 7(18), 3077-3080 (1996-11-25)
Since administration of anti-inflammatory drugs has been reported to possibly slow the progression of Alzheimer's disease, an effort was made to define effector functions induced by beta-amyloid (A beta) which may be inhibited by these drugs. Rat microglia in culture
P E Fraser et al.
Journal of neuroscience research, 28(4), 474-485 (1991-04-01)
To elucidate the relationship between amyloid fibril formation in Alzheimer disease (AD) and the primary structure of the beta-amyloid protein (beta-AP), we investigated the ability of peptides sharing sequences with beta-AP to form fibrils in vitro and to recognize anti-beta-amyloid

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