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重要文件

88185

Sigma-Aldrich

四唑 溶液

suitable for DNA synthesis, filtered through a 1 μm filter, ~0.45 M in acetonitrile

同義詞:

1H-Tetrazole

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About This Item

經驗公式(希爾表示法):
CH2N4
CAS號碼:
分子量::
70.05
Beilstein:
105799
MDL號碼:
分類程式碼代碼:
12352100
PubChem物質ID:
NACRES:
NA.21
bp:
84 °C (lit.)

形狀

liquid

品質等級

品質

filtered through a 1 μm filter

濃度

~0.45 M in acetonitrile

技術

DNA synthesis: suitable

雜質

≤0.003% water

bp

84 °C (lit.)

mp

156-158 °C (lit.)

密度

0.798 g/mL at 20 °C

SMILES 字串

c1nnn[nH]1

InChI

1S/CH2N4/c1-2-4-5-3-1/h1H,(H,2,3,4,5)

InChI 密鑰

KJUGUADJHNHALS-UHFFFAOYSA-N

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一般說明

本品为约 0.45M 四唑乙腈溶液。四唑环在各种合成和工业生产过程中起重要的作用。

應用

四唑溶液可用于 DNA 合成。它可用作在原位 合成脱氧核苷亚磷酰胺的催化剂。可用于制备以下阴离子核苷酸脂质:
  • 胸苷 3′-(1,2-二苯甲酰--甘油-3-磷酸),diC 12 -3′-dT
  • 胸苷 3′-(1,2-二肉豆蔻酰--甘油-3-磷酸)diC 14 -3′-dT
  • 胸苷-3′-(1,2-二棕榈酰--甘油-3-磷酸)diC 16 -3′-dT

注意

室温下为饱和溶液;低于室温储存会产生沉淀。

其他說明

寡核苷酸亚磷酸三酯法合成(二烷基氨基)膦偶联用催化剂

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產品號碼
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訂價

象形圖

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訊號詞

Danger

危險分類

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2

儲存類別代碼

3 - Flammable liquids

水污染物質分類(WGK)

WGK 3

閃點(°F)

41.0 °F - closed cup

閃點(°C)

5 °C - closed cup

個人防護裝備

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter


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Azidoazomethine-tetrazole isomerism in solution: A thermochemical study.
Cubero E, et al.
The Journal of Organic Chemistry, 63(7), 2354-2356 (1998)
A D Barone et al.
Nucleic acids research, 12(10), 4051-4061 (1984-05-25)
Deoxynucleoside phosphoramidites can be prepared in good yield from deoxynucleosides, bis- dialkylaminophosphines , and the corresponding dialkylamine hydrotetrazolide or tetrazole as catalysts. These phosphoramidites generated in situ lead to the direct synthesis of deoxyoligonucleotides on polymer supports.
Salim Khiati et al.
Bioconjugate chemistry, 20(9), 1765-1772 (2009-08-29)
A family of new anionic nucleotide based lipids featuring thymidine-3'-monophosphate as nucleotide and 1,2-diacyl-sn-glycerol as lipid moiety for in vitro delivery of nucleic acids is described. The nucleotide lipids were prepared in three steps starting from 1,2-diacyl-sn-glycerols and 2'-deoxythymidine-3'-phosphoramidite. Gel
J Nielsen et al.
Nucleic acids research, 14(18), 7391-7403 (1986-09-25)
Deoxyribonucleoside phosphoramidites are prepared in situ from 5'-O,N-protected deoxyribonucleosides and 2-cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite with tetrazole as catalyst, and the solutions applied directly on an automatic solid-phase DNA synthesizer. Using LCAA-CPG support and a cycle time of 12.5 min, oligonucleotides of 16-25
Adina Morozan et al.
ChemSusChem, 5(4), 647-651 (2012-03-06)
High-performance oxygen reduction reaction (ORR) catalysts based on metal-free nitrogen-containing precursors and carbon nanotubes are reported. The investigated systems allow the evaluation of the effect of nitrogen-containing groups towards ORR and the results show that the catalysts are compatible with

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