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About This Item
經驗公式（希爾表示法）:
C17H13ClNO5P
CAS號碼:
分子量：:
377.72
Beilstein:
6664478
EC號碼:
MDL號碼:
分類程式碼代碼:
12352204
PubChem物質ID:
NACRES:
NA.83
推薦產品
應用
Naphthol AS-E磷酸盐已被用作cAMP反应元件结合蛋白（CREB）的抑制剂，以溶解于二甲基亚砜（DMSO）中作为研究中的储存溶液，来验证制癌蛋白M（OSM）可能会赋予针对3-硝基丙酸（3-NP）的神经元抗性的假设。
生化／生理作用
Naphthol AS-E磷酸盐/KG501是一种小分子拮抗剂，具有阻止cAMP反应元件结合蛋白（CREB）通路的能力。它还可在体外干扰Myb-KIX的相互作用并阻断Myb在体内的作用。
其他說明
碱性磷酸酶的组织化学底物，KG-501可通过干扰CREB的KID结构域和CBP（CREB结合蛋白）的KIX结构域之间这一经典的激活剂-共激活因子互作结合，来阻断CREB（cAMP反应元件结合蛋白）依赖性靶基因转录（Ki 10 microM）的cAMP-诱导。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
Naphthol AS-E phosphate inhibits the activity of the transcription factor Myb by blocking the interaction with the KIX domain of the coactivator p300
Uttarkar S, et al.
Molecular Cancer Therapeutics, molcanther-molcan0662 (2015)
Phosphates of the naphthol AS series in the quantitative determination of alkaline and acid phosphatase activities in situ studied in polyacrylamide membrane model systems and by cytospectrophotometry
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我們的科學家團隊在所有研究領域都有豐富的經驗，包括生命科學、材料科學、化學合成、色譜、分析等.
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