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69591

Sigma-Aldrich

4-甲基伞形酮 α- D -吡喃葡萄糖苷

≥98% (TLC)

同義詞:

4-甲基伞形酮 α- D -葡萄糖苷

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About This Item

經驗公式(希爾表示法):
C16H18O8
CAS號碼:
分子量::
338.31
Beilstein:
1690776
EC號碼:
MDL號碼:
分類程式碼代碼:
12352204
PubChem物質ID:
NACRES:
NA.25

描述

α-glucosidase substrate

品質等級

化驗

≥98% (TLC)

形狀

powder

溶解度

DMSO: 50 mg/mL, clear, colorless to faintly yellow

螢光

λex 316 nm; λem 375 nm (Reaction product)
λex 317 nm; λem 374 nm (pH9.0)
λex 360 nm; λem 449 nm
λex 365 nm; λem 445 nm in 0.1 M Tris pH 8.0 (α-glucosidase)

儲存溫度

−20°C

SMILES 字串

CC1=CC(=O)Oc2cc(O[C@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)ccc12

InChI

1S/C16H18O8/c1-7-4-12(18)23-10-5-8(2-3-9(7)10)22-16-15(21)14(20)13(19)11(6-17)24-16/h2-5,11,13-17,19-21H,6H2,1H3/t11-,13-,14+,15-,16+/m1/s1

InChI 密鑰

YUDPTGPSBJVHCN-JZYAIQKZSA-N

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一般說明

4-甲基伞形酮α-D-吡喃葡萄糖苷是 α -葡萄糖苷酶的荧光底物。 4-甲基伞形酮α-D-吡喃葡萄糖苷,又称 4MU- α-glc,反应后生成产物 4MU,其荧光光谱峰值为 440nm。

應用

4-甲基伞形酮α-D-吡喃葡萄糖苷可作为荧光底物,用于α-D-葡萄糖苷酶的鉴别、表征和动力学分析。4-甲基伞形酮α-D-吡喃葡萄糖苷用于高通量筛选实验。它适用于肾脏及白细胞的庞佩氏症诊断。

包裝

无底玻璃瓶。内容物在插入的熔锥内。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


分析證明 (COA)

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A.Holzapfel-Pschorn et al.
Fresenius Journal of Analytical Chemistry, 327, 521-521 (1987)
Shohei Shigeto et al.
Molecular genetics and metabolism, 103(1), 12-17 (2011-02-16)
The high frequency (3.3-3.9%) of acid α-glucosidase pseudodeficiency, c.[1726G>A; 2065G>A] homozygote (AA homozygote), in Asian populations complicates newborn screening for Pompe disease (glycogen storage disease type II or acid maltase deficiency) on dried blood spots, since AA homozygotes have a
D M Broadhead et al.
Clinical genetics, 13(6), 504-510 (1978-06-01)
The diagnosis of Pompe's disease by the assay of acid alpha-glucosidase in kidney and leucocytes was not previously possible because of the presence of another component which had activity at pH 4.0, but was not deficient in the disease. This
Reporter bacteriophage A511::celB transduces a hyperthermostable glycosidase from Pyrococcus furiosus for rapid and simple detection of viable Listeria cells.
Hagens S, de Wouters T, et al.
Bacteriophages, 1, 143-151 (2011)
Lara W Katzin et al.
Journal of clinical neuromuscular disease, 9(4), 421-431 (2008-06-06)
Pompe disease, or glycogen storage disease type II, is a rare autosomal recessive disorder caused by mutations in the gene that encodes for alpha-glucosidase. Presentation in infancy is associated with respiratory failure, cardiomyopathy, and severe muscle weakness. Juvenile- or adult-onset

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