481M-9

PAX-7 (MRQ-69) Mouse Monoclonal Antibody

• 分類程式碼代碼: 12352203

屬性

• 生物源: mouse
• 品質等級: 100; 500
• 共軛: unconjugated
• 抗體表格: culture supernatant
• 抗體產品種類: primary antibodies
• 無性繁殖: MRQ-69, monoclonal
• 描述: For In Vitro Diagnostic Use in Select Regions
• 形狀: buffered aqueous solution
• 物種活性: human
• 包裝: vial of 0.1 mL concentrate (481M-94); vial of 0.1 mL concentrate Research Use Only (481M-94-RUO); vial of 0.5 mL concentrate (481M-95); vial of 1.0 mL concentrate (481M-96); vial of 1.0 mL concentrate Research Use Only (481M-96-RUO); vial of 1.0 mL pre-dilute Research Use Only (481M-97-RUO); vial of 1.0 mL pre-dilute ready-to-use (481M-97); vial of 7.0 mL pre-dilute ready-to-use (481M-98); vial of 7.0 mL pre-dilute ready-to-use Research Use Only (481M-98-RUO)
• 製造商／商標名: Cell Marque^™
• 技術: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:200 (concentrated)
• 同型: IgG
• 控制: Ewing’s sarcoma, rhabdomyosarcoma
• 運輸包裝: wet ice
• 儲存溫度: 2-8°C
• 視覺化: nuclear

描述

一般說明

The paired-box (PAX) family of proteins are key transcriptional regulators involved in early critical development.¹ The PAX-7 transcription factor has important functions in mammalian myogenesis and early neural development, with a particularly crucial role in specification and self-renewal of skeletal muscle tissue.^2,3 The expression of PAX-7 is highly restricted in normal adult tissues as demonstrated by nuclear immunoreactivity only being identified in rare, scattered satellite cells of the skeletal muscle and absent in both visceral smooth muscle and cardiac muscle as well as in a broad anatomical range of other non-neoplastic tissues. The assessment of soft tissue tumors and small round cell tumors is a persistent diagnostic challenge because of overlapping morphological features and insufficient molecular characterization in these groups of neoplasms. A high frequency of strong PAX-7 nuclear expression has been identified predominantly in rhabdomyosarcomas, preferentially in the embryonal subtype, and Ewing′s sarcoma, with reactivity being absent in related malignancies such as leiomyosarcoma, lymphoblastic lymphoma, neuroblastoma, carcinoid tumor, gastrointestinal stromal tumor, and small cell lung carcinoma. Immunohistochemical detection of PAX-7 protein can be used as a tool in distinguishing embryonal rhabdomyosarcoma and Ewing′s sarcoma from histologic mimics.^4,5

品質

United States - IVD
Canada - RUO
European Union - IVD
Japan - RUO

外觀

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

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其他說明

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

法律資訊

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany