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Merck
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重要文件

475R-9

Sigma-Aldrich

INSM1 (MRQ-70) Rabbit Monoclonal Antibody

同義詞:

Insulinoma-associated protein 1

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About This Item

分類程式碼代碼:
12352203

生物源

rabbit

品質等級

100
500

共軛

unconjugated

抗體表格

culture supernatant

抗體產品種類

primary antibodies

無性繁殖

MRQ-70, monoclonal

描述

For In Vitro Diagnostic Use in Select Regions

形狀

buffered aqueous solution

物種活性

human

包裝

vial of 0.1 mL concentrate (475R-94)
vial of 0.1 mL concentrate Research Use Only (475R-94-RUO)
vial of 0.5 mL concentrate (475R-95)
vial of 1.0 mL concentrate (475R-96)
vial of 1.0 mL concentrate Research Use Only (475R-96-RUO)
vial of 1.0 mL pre-dilute Research Use Only (475R-97-RUO)
vial of 1.0 mL pre-dilute ready-to-use (475R-97)
vial of 7.0 mL pre-dilute ready-to-use (475R-98)
vial of 7.0 mL pre-dilute ready-to-use Research Use Only (475R-98-RUO)

製造商／商標名

Cell Marque™

技術

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100 (concentrated)

同型

IgG

控制

pancreas

運輸包裝

wet ice

儲存溫度

2-8°C

視覺化

nuclear

相關類別

一般說明

Insulinoma-associated protein 1 (INSM1) is a transcriptional factor with a zinc finger DNA-binding domain that is involved in neuroendocrine cell differentiation as a transcriptional repressor1. INSM1 expression has been observed during embryonic development in the cerebellum, spinal cord, olfactory epithelium, pancreas, and gastrointestinal tract2-4; however, expression in healthy adult tissues is limited to neuroendocrine cells. INSM1 is over expressed in neuroendocrine neoplasms including carcinoids, small cell carcinomas, and neuroendocrine carcinomas. This helps in identification of neuroendocrine tumors and their distinction from other lesions, such as adenocarcinomas, which exhibit little to no INSM1 expression5-6.

品質

United States - IVD
Canada - RUO
European Union - IVD
Japan - RUO

外觀

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

準備報告

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其他說明

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

法律資訊

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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儲存類別代碼

12 - Non Combustible Liquids

水污染物質分類（WGK）

WGK 2

閃點（°F）

Not applicable

閃點（°C）

Not applicable

分析證明 (COA)

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存取文件庫

Sanjay Mukhopadhyay et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 32(1), 100-109 (2018-08-30)
Recent evidence suggests a role for the nuclear marker INSM1 in the diagnosis of neuroendocrine lung neoplasms. The aim of this study was to determine the utility of INSM1 as a marker of neuroendocrine differentiation using a large series of
Lilla M Farkas et al.
Neuron, 60(1), 40-55 (2008-10-23)
Basal (intermediate) progenitors are the major source of neurons in the mammalian neocortex. The molecular machinery governing basal progenitor biogenesis is unknown. Here, we show that the zinc-finger transcription factor Insm1 (insulinoma-associated 1) is expressed specifically in progenitors undergoing neurogenic
Mathias S Gierl et al.
Genes & development, 20(17), 2465-2478 (2006-09-05)
The pancreatic and intestinal primordia contain epithelial progenitor cells that generate many cell types. During development, specific programs of gene expression restrict the developmental potential of such progenitors and promote their differentiation. The Insm1 (insulinoma-associated 1, IA-1) gene encodes a
Jason N Rosenbaum et al.
Neural development, 6, 6-6 (2011-02-03)
Insm1 is a zinc-finger transcription factor transiently expressed throughout the developing nervous system in late progenitors and nascent neurons. Insm1 is also highly expressed in medulloblastomas and other neuroendocrine tumors. We generated mice lacking the Insm1 gene and used them
Michael S Lan et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 23(7), 2024-2033 (2009-02-28)
Zinc-finger transcription factors are DNA-binding proteins that are implicated in many diverse biological functions. INSM1 (formerly IA-1) contains five zinc-finger motifs and functions as a transcription factor. INSM1 protein structure is highly conserved in homologues of different species. It is

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