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重要文件

44270

Sigma-Aldrich

反式反式-法尼基焦磷酸 铵盐

≥95.0% (HPLC)

同義詞:

法尼基二磷酸酯 铵盐, (E,E)-3,7,11-三甲基-2,6,10-十二碳三烯-1-基焦磷酸盐 铵盐

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About This Item

經驗公式(希爾表示法):
C15H28O7P2 · xNH3
分子量::
382.33 (free acid basis)
Beilstein:
2482197
分類程式碼代碼:
12352212
PubChem物質ID:
NACRES:
NA.25

等級

for analytical purposes

化驗

≥95.0% (HPLC)

形狀

solid

儲存溫度

−20°C

SMILES 字串

N.C\C(C)=C\CC\C(C)=C\CC\C(C)=C\COP(O)(=O)OP(O)(O)=O

InChI

1S/C15H28O7P2.H3N/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-21-24(19,20)22-23(16,17)18;/h7,9,11H,5-6,8,10,12H2,1-4H3,(H,19,20)(H2,16,17,18);1H3/b14-9+,15-11+;

InChI 密鑰

CPYJTMLHKIWGDF-NDHHSALASA-N

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相關類別

應用

法尼基二磷酸铵盐可用于研究称为法呢基化的翻译后过程,其用于修饰重要蛋白质,例如Ras癌基因。

生化/生理作用

法尼基焦磷酸盐是更复杂的倍半萜类化合物、萜类化合物和类固醇的生物合成中的关键中间体,并且 FPP 和相应的醇法尼醇具有不同生物学功能。FPP 在 Ras 蛋白的翻译后加工中起重要作用。Ras 的突变形式与人类癌症相关,因此在癌症研究中进行了研究

包裝

无底玻璃瓶。内含物装在插入的融合锥内。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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分析證明 (COA)

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Po-Huang Liang et al.
European journal of biochemistry, 269(14), 3339-3354 (2002-07-24)
In this review, we summarize recent progress in studying three main classes of prenyltransferases: (a) isoprenyl pyrophosphate synthases (IPPSs), which catalyze chain elongation of allylic pyrophosphate substrates via consecutive condensation reactions with isopentenyl pyrophosphate (IPP) to generate linear polymers with
S M Sebti et al.
Oncogene, 19(56), 6584-6593 (2001-06-28)
In 1990, more than 10 years after the discovery that the low molecular weight GTPase Ras is a major contributor to human cancer, farnesylation, a lipid posttranslational modification required for the cancer-causing activity of Ras, emerged as a major target
Farnesyl Diphosphate Analogues with Aryl Moieties Are Efficient Alternate Substrates for Protein Farnesyltransferase.
Subramanian T, Pais JE, Liu S, et al.
Biochemistry (2012)
Norbert Berndt et al.
Nature protocols, 6(11), 1775-1791 (2011-11-01)
The importance of the post-translational lipid modifications farnesylation and geranylgeranylation in protein localization and function coupled with the critical role of prenylated proteins in malignant transformation has prompted interest in their biology and the development of farnesyl transferase and geranylgeranyl
H Xie et al.
The Journal of organic chemistry, 65(25), 8552-8563 (2000-12-12)
The a-factor of Saccharomyces cerevisiae is a dodecapeptide pheromone (YIIKGVFWDPAC(Farnesyl)-OCH(3), 1), in which post-translational modification with a farnesyl isoprenoid and carboxymethyl group is required for full biological activity. This peptide has been used as a model system to explore the

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