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Merck
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Key Documents

406OA-05A

Sigma-Aldrich

Human Osteoblasts-Osteoarthritis: HOb-OA, adult

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About This Item

分類程式碼代碼:
41106514
NACRES:
NA.81

生物源

human bone (osteoarthritic)

品質等級

包裝

pkg of 500,000 cells

製造商/商標名

Cell Applications, Inc

增長模式

Adherent

染色體組型

2n = 46

形態學

osteoblast

技術

cell culture | mammalian: suitable

相關疾病

arthritis

運輸包裝

dry ice

儲存溫度

−196°C

一般說明

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Human Osteoblasts-Osteoarthritis, HOb-OA, are isolated from bone of patients with osteoarthritis (OA) and provide an excellent model system to study the patophisiology of that disease in vitro, including matrix mineralization, effects of inflammatory mediators and bone morphogenic proteins, physiological control of bone remodeling and regulation of bone metabolism.

Characterization: Positive for bone mineralization.

細胞系來源

Bone

應用

model system to study the pathophisiology of osteoarthritis, matrix mineralization, effects of inflammatory mediators, bone morphogenic proteins, bone remodeling and metabolism

成分

Basal Medium containing 10% FBS & 10% DMSO

準備報告

  • 2nd passage, >500,000 cells in Basal Medium containing 10% FBS & 10% DMSO
  • Can be cultured at least 10 doublings

例行更新培養

Please refer to the HOb-OA Culture Protocol.

免責聲明

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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Xiangxiang Sun et al.
International journal of biological sciences, 16(6), 994-1009 (2020-03-07)
Osteoarthritis (OA) is a common type of arthritis. Chronic inflammation is an important contributor to the pathogenesis of OA. The maturation and secretion of proinflammatory cytokines are controlled by inflammasomes, especially NLRP1 (NLR Family Pyrin Domain Containing 1) and NLRP3.

條款

Store the cryovials in a liquid nitrogen storage tank immediately upon arrival.

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