378R-1

Cadherin-17 (SP183) Rabbit Monoclonal Antibody

• 分類程式碼代碼: 12352200
• NACRES: NA.41

屬性

• 生物源: rabbit
• 品質等級: 100; 500
• 共軛: unconjugated
• 抗體表格: culture supernatant
• 抗體產品種類: primary antibodies
• 無性繁殖: SP183, monoclonal
• 描述: For In Vitro Diagnostic Use in Select Regions (See Chart)
• 形狀: buffered aqueous solution
• 物種活性: human
• 包裝: vial of 0.1 mL concentrate (378R-14); vial of 0.5 mL concentrate (378R-15); bottle of 1.0 mL predilute (378R-17); vial of 1.0 mL concentrate (378R-16); bottle of 7.0 mL predilute (378R-18)
• 製造商／商標名: Cell Marque^™
• 技術: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500
• 同型: IgG
• 控制: colorectal carcinoma
• 運輸包裝: wet ice
• 儲存溫度: 2-8°C
• 視覺化: cytoplasmic, membranous
• 基因資訊: human ... CDH17(1015)

描述

一般說明

Cadherin-17, also called liver-intestinal (LI) cadherin or human peptide transporter-1, is a member of the cadherin superfamily. Unlike some classic cadherins, such as E-, N-, and P-cadherins, cadherin-17 has seven cadherin repeats instead of five within the extracellular domain and only 20 amino-acid residues in the cytoplasmic domain. The markedly short cytoplasmic domain lacks homology with other cadherins and the adhesive function of cadherin-17 is not dependent on association with other cytoplasmic proteins. The subcellular distribution of cadherin-17 is also different from classic cadherins. In intestinal epithelial cells, E-cadherin is concentrated in adherens junctions whereas cadherin-17 is evenly distributed along the lateral contact area. Human normal tissues that are strongly stained with cadherin-17 include appendicular epithelium, colonic epithelium, and small intestinal epithelium. Other normal human tissues are not stained with cadherin-17. The results above indicate cadherin-17 can be used as a marker for identification of primary sites of tumors. In-house studies have shown that cadherin-17 expression is usually diffuse and strong in colorectal adenocarcinomas, whereas it is usually focal or scattered in adenocarcinomas of the stomach, pancreas and bile duct, and is virtually absent in tumors of other anatomic sites.

品質

IVD

IVD

IVD

RUO

聯結

Cadherin-17 Positive Control Slides, Product No. 378S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

外觀

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

準備報告

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

其他說明

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

法律資訊

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany