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Sigma-Aldrich

1-硝基吡咯烷

99%

同義詞:

N-亚硝基吡咯烷, NPYR

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About This Item

經驗公式（希爾表示法）:
C4H8N2O
CAS號碼:
930-55-2
分子量：:
100.12
EC號碼:
213-218-8
MDL號碼:
MFCD00003166
分類程式碼代碼:
12352200
PubChem物質ID:
57647525
NACRES:
NA.25

化驗

99%

折射率

n20/D 1.489 (lit.)

bp

214 °C (lit.)

密度

1.085 g/mL at 25 °C (lit.)

SMILES 字串

O=NN1CCCC1

InChI

1S/C4H8N2O/c7-5-6-3-1-2-4-6/h1-4H2

InChI 密鑰

WNYADZVDBIBLJJ-UHFFFAOYSA-N

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應用

1-硝基吡咯烷可用于研究致癌物和癌症。已在大鼠中检测了体内亚硝胺的代谢。1-硝基吡咯烷已用于研究鸡胚中的一氧化氮和自发收缩活动。

生化／生理作用

在小鼠中诱发肝细胞癌和肺腺瘤。形成主要导致 A：T 到 G：C 突变的 DNA 加合物。

象形圖

Health hazardExclamation mark
GHS08,GHS07

訊號詞

Warning

危險聲明

H302,H351

危險分類

Acute Tox. 4 Oral - Carc. 2

儲存類別代碼

10 - Combustible liquids

水污染物質分類（WGK）

WGK 3

閃點（°F）

208.4 °F - closed cup

閃點（°C）

98 °C - closed cup

個人防護裝備

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

分析證明 (COA)

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N-亚硝基二苯胺 溶液

Mingyao Wang et al.
Chemical research in toxicology, 20(4), 625-633 (2007-03-31)
N-Nitrosopyrrolidine (NPYR) is a well-established hepatocarcinogen in the rat. NPYR requires metabolic activation by cytochrome P450-catalyzed alpha-hydroxylation to express its carcinogenic activity. This produces alpha-hydroxyNPYR (2), which spontaneously ring opens to 4-oxobutanediazohydroxide (4), a highly reactive intermediate, which may itself
Keita Kanki et al.
Molecular carcinogenesis, 42(1), 9-17 (2004-10-16)
In order to cast light on carcinogen-specific molecular mechanisms underlying experimental hepatocarcinogenesis in rats, in vivo mutagenicity and mutation spectra of known genotoxic rat hepatocarcinogens N-nitrosopyrrolidine (NPYR), and 2-amino-3-methylimidazo[4,5-f]quinoline (IQ), as well as the nongenotoxic hepatocarcinogen di(2-ethylhexyl)phthalate (DEHP) and the
Nuria Arranz et al.
Journal of applied toxicology : JAT, 26(5), 466-473 (2006-07-28)
The aim of this study was to investigate the protective effect of isothiocyanates towards N-nitrosamine-induced DNA damage in the single-cell gel electrophoresis (SCGE)/HepG2 assay. None of the isothiocyanates (ITCs) concentrations tested in the presence or absence of formamidopyrimidine-DNA glycosylase (Fpg)
Jia Yuan Yang et al.
Journal of hazardous materials, 176(1-3), 602-608 (2009-12-22)
A new route to modify the mesoporous silica MCM-41 with carbon, using the inherent surfactant template in the as-synthesized sample as the carbon precursor, is reported in this article. Apart from the advantage of omitting energy and time required for
Mingyao Wang et al.
Chemical research in toxicology, 20(4), 634-640 (2007-03-31)
N-Nitrosopyrrolidine (NPYR) is a hepatocarcinogen in rats. It is metabolically activated by cytochrome P450 enzymes in the liver leading to the formation of 4-oxobutanediazohydroxide (4) and related intermediates that react with DNA to form adducts. Because DNA adducts are thought
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DNA damage and repair mechanism is vital for maintaining DNA integrity. Damage to cellular DNA is involved in mutagenesis, the development of cancer among others.

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