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重要文件

123R-2

Sigma-Aldrich

CD23 (EP75) Rabbit Monoclonal Primary Antibody

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About This Item

分類程式碼代碼:
12352203

生物源

rabbit

共軛

unconjugated

抗體表格

culture supernatant

抗體產品種類

primary antibodies

無性繁殖

EP75, monoclonal

描述

For In Vitro Diagnostic Use in Select Regions

形狀

buffered aqueous solution

物種活性

human

包裝

vial of 0.1 mL concentrate (123R-24)
vial of 0.1 mL concentrate Research Use Only (123R-24-RUO)
vial of 0.5 mL concentrate (123R-25)
vial of 1.0 mL concentrate (123R-26)
vial of 1.0 mL concentrate Research Use Only (123R-26-RUO)
vial of 1.0 mL pre-dilute Research Use Only (123R-27-RUO)
vial of 1.0 mL pre-dilute ready-to-use (123R-27)
vial of 7.0 mL pre-dilute ready-to-use (123R-28)
vial of 7.0 mL pre-dilute ready-to-use Research Use Only (123R-28-RUO)

製造商/商標名

Cell Marque

技術

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500 (concentrated)

同型

IgG

控制

chronic lymphocytic leukemia, lymph node, small lymphocytic lymphoma, tonsil

運輸包裝

wet ice

儲存溫度

2-8°C

視覺化

membranous

基因資訊

human ... FCER2(2208)

一般說明

CD23 antigen is a 45-60 kDa membrane glycoprotein identified as a low affinity receptor for IgE production as well as a receptor for lymphocyte growth factor. CD23 is found in some mature B-cell lymphomas and in Reed-Sternberg cells in Hodgkin disease. Follicular dendritic cells and some activated B-cells within germinal centers express CD23 in high density and mantle zone B-cells are stained weakly. The majority of chronic lymphocytic leukemias/small lymphocytic lymphomas are CD23 positive, whereas mantle cell lymphomas are generally negative, so this marker is useful when applied with other markers to separate the small cell lymphomas. Precursor B and T lymphomas, myeloid neoplasms, and mature T-cell lymphomas are CD23 negative and other small cell lymphomas are occasionally positive. CD23 is also positive on activated mature B-cells expressing IgM or IgD, monocytes/macrophages, follicular dendritic cells, T-cell subsets, eosinophils, Langerhans cells and small lymphocytic lymphoma/chronic lymphocytic leukemia (SLL/CLL).

品質

United States - IVD
Canada - IVD
European Union - RUO
Japan - RUO

聯結

CD23 Positive Control Slides, Product No. 123S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

外觀

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

準備報告

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其他說明

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

法律資訊

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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儲存類別代碼

12 - Non Combustible Liquids

水污染物質分類(WGK)

WGK 2

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Francesco DiRaimondo et al.
Cancer, 94(6), 1721-1730 (2002-03-29)
CD23 antigen is a cell surface protein considered important in the differentiation of chronic lymphocytic leukemia (CLL) from other lymphoid leukemias. To better clarify CD23 role as a diagnostic tool, the authors retrospectively evaluated clinical and laboratory features of 372

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