Y0001761

尼可地尔

European Pharmacopoeia (EP) Reference Standard

• 同義詞: 2-(吡啶-3-羰基氨基)乙基硝酸酯, 2-烟酰胺基硝酸乙酯, N-[2-硝氧乙基]-3-吡啶键酰胺, SG-75, 尼可地尔, 烟浪丁
• 經驗公式（希爾表示法）: C₈H₉N₃O₄
• CAS號碼: 65141-46-0
• 分子量：: 211.17
• MDL號碼: MFCD00186520
• 分類程式碼代碼: 41116107
• PubChem物質ID: 329831558
• NACRES: NA.24

屬性

• 等級: pharmaceutical primary standard
• API 家族: nicorandil
• 製造商／商標名: EDQM
• 應用: pharmaceutical (small molecule)
• 格式: neat
• 儲存溫度: −20°C
• SMILES 字串: [O-][N+](=O)OCCNC(=O)c1cccnc1
• InChI: 1S/C8H9N3O4/c12-8(7-2-1-3-9-6-7)10-4-5-15-11(13)14/h1-3,6H,4-5H2,(H,10,12)
• InChI 密鑰: LBHIOVVIQHSOQN-UHFFFAOYSA-N

描述

一般說明

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

應用

Nicorandil EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

生化／生理作用

尼可地尔是一种杂合ATP敏感性K+（KATP）通道开放剂，也是烟酰胺硝酸盐NO供体。尼可地尔能够选择性激活含有SUR2B-和SUR2A-的KATP通道。它可以增强内皮NO合酶的表达，并防止缺血性室性心律失常。尼可地尔通过激活钾离子通道并提供一氧化氮激活鸟苷酸环化酶，引起GMP活化，从而导致动脉和静脉血管舒张。尼可地尔对血管钾离子通道具有选择性，但对心肌收缩和传导没有明显作用。

包裝

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

其他說明

Sales restrictions may apply.

安全資訊

• 象形圖: GHS02,GHS07
• 訊號詞: Danger
• 危險聲明: H242,H302
• 防範說明: P210 - P235 - P280 - P301 + P312 - P370 + P378 - P410
• 危險分類: Acute Tox. 4 Oral - Org. Perox. D
• 儲存類別代碼: 5.2 - Organic peroxides and self-reacting hazardous materials
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable