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重要文件

Y0000734

达卡巴嗪杂质A

European Pharmacopoeia (EP) Reference Standard

同義詞:

3,7-Dihydro-4H-imidazo[4,5-d]-1,2,3-triazin-4-one, 2-Azahypoxanthine, NSC 22419

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About This Item

經驗公式(希爾表示法):
C4H3N5O
CAS號碼:
分子量::
137.10
分類程式碼代碼:
41116107
NACRES:
NA.24

等級

pharmaceutical primary standard

API 家族

dacarbazine

製造商/商標名

EDQM

應用

pharmaceutical (small molecule)

形式

neat

儲存溫度

2-8°C

InChI

1S/C4H3N5O/c10-4-2-3(6-1-5-2)7-9-8-4/h1,9H,(H,8,10)

InChI 密鑰

WXKVKFJUCMCVFI-UHFFFAOYSA-N

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一般說明

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

應用

Dacarbazine impurity A EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

包裝

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

其他說明

Sales restrictions may apply.

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Disclosure of the "fairy" of fairy-ring-forming fungus Lepista sordida.
Jae-Hoon Choi et al.
Chembiochem : a European journal of chemical biology, 11(10), 1373-1377 (2010-05-21)
D Fiore et al.
Antimicrobial agents and chemotherapy, 27(6), 977-979 (1985-06-01)
A high-pressure liquid chromatographic method has been developed that allows for the simultaneous analysis of dacarbazine (DTIC), 5-aminoimidazole-4-carboxamide (AIC), and 2-azahypoxanthine (2-AZA) in plasma or urine. Plasma samples were prepared by ultrafiltration, whereas urine samples were filtered and diluted for
B Hernández et al.
Journal of computer-aided molecular design, 11(2), 153-162 (1997-03-01)
The tautomerism of 2-azaadenine and 2-hypoxanthine has been examined in the gas phase and in aqueous solution. The tautomerism in the gas phase has been studied by means of semiempirical and ab initio quantum-mechanical computations, as well as density-functional calculations.
L L Bennett et al.
Biochemical pharmacology, 34(8), 1293-1304 (1985-04-15)
The metabolism and metabolic effects of 2-azahypoxanthine and 2-azaadenosine were studied to elucidate the biochemical basis for their known cytotoxicities. 2-Azaadenosine is a known substrate for adenosine kinase. That 2-azahypoxanthine is a substrate for hypoxanthine (guanine) phosphoribosyltransferase is shown by
P P Saunders et al.
Chemico-biological interactions, 58(3), 319-331 (1986-06-01)
Decomposition of the antitumor agent 5-(3,3-dimethyl-1-triazeno)imidazole-4-carboxamide (DTIC, Dacarbazine) produces several potentially toxic compounds, the concentration of which depend on incubation parameters such as pH, temperature and illumination. The action of DTIC on chinese hamster ovary (CHO) cell clone formation in

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