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Key Documents

Y0000507

氯丙嗪杂质A

European Pharmacopoeia (EP) Reference Standard

同義詞:

Chlorpromazine sulfoxide, 3-(2-Chloro-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1- amine S-oxide

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About This Item

經驗公式(希爾表示法):
C17H19ClN2OS
CAS號碼:
分子量::
334.86
分類程式碼代碼:
41116107
NACRES:
NA.24

等級

pharmaceutical primary standard

API 家族

chlorpromazine

製造商/商標名

EDQM

應用

pharmaceutical (small molecule)

格式

neat

儲存溫度

2-8°C

InChI

1S/C17H19ClN2OS/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)22(21)17-9-8-13(18)12-15(17)20/h3-4,6-9,12H,5,10-11H2,1-2H3

InChI 密鑰

QEPPAOXKZOTMPM-UHFFFAOYSA-N

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一般說明

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

應用

Chlorpromazine impurity A EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

包裝

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

其他說明

Sales restrictions may apply.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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J W Hubbard et al.
Therapeutic drug monitoring, 7(2), 222-228 (1985-01-01)
Pooled plasma from healthy volunteers was spiked with pure, synthetic chlorpromazine (CPZ), chlorpromazine sulfoxide (CPZSO), or chlorpromazine N-oxide (CPZNO), and then made alkaline with either sodium hydroxide or sodium carbonate. The samples were allowed to stand at room temperature for
M Nakano et al.
Biochemical and biophysical research communications, 130(3), 952-956 (1985-08-15)
Chemiluminescence in visible region was detected, during peroxidase-catalyzed oxidation of chlorpromazine at pH7.5 (but not at pH4.25) or of propericiazine, both at pH7.5 and at pH4.25. Red colored intermediates, cation radicals, were produced and decayed in all enzymatic systems used.
P K Yeung et al.
The Journal of pharmacology and experimental therapeutics, 226(3), 833-838 (1983-09-01)
Antibody specific for chlorpromazine sulfoxide (CPZSO) was produced in rabbits immunized with a hapten-bovine serum albumin conjugate, which was prepared by linking the 10-alkyl side chain of CPZSO to the protein molecule via a 2-carbon bridge. A simple radioimmunoassay was
Free radical production by chlorpromazine sulfoxide, an ESR spin-trapping and flash photolysis study.
G R Buettner et al.
Photochemistry and photobiology, 44(1), 5-10 (1986-07-01)
Z Y Sahaf et al.
Brain research, 437(2), 397-401 (1987-12-29)
Treatment of frog neuromuscular preparations with chlorpromazine (5 mumol/l) resulted in a marked rise in miniature endplate potential (MEPP) frequency of greater than 100% within 30 min, and an increase in evoked transmitter release (quantal content 5-15) of about 35%.

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