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重要文件

Y0000109

硫柳汞钠

European Pharmacopoeia (EP) Reference Standard

同義詞:

Mercury-([o-carboxyphenyl]thio)ethyl 钠盐, 乙基噻吩酸 钠盐, 乙汞硫柳酸钠, 乙汞硫水杨酸 钠盐

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About This Item

線性公式:
2-(C2H5HgS)C6H4CO2Na
CAS號碼:
分子量::
404.81
Beilstein:
8169555
MDL號碼:
分類程式碼代碼:
41116107
PubChem物質ID:
NACRES:
NA.24

等級

pharmaceutical primary standard

API 家族

thimerosal

製造商/商標名

EDQM

mp

234-237 °C (dec.) (lit.)

應用

pharmaceutical (small molecule)

形式

neat

儲存溫度

2-8°C

SMILES 字串

[Na+].CC[Hg]Sc1ccccc1C([O-])=O

InChI

1S/C7H6O2S.C2H5.Hg.Na/c8-7(9)5-3-1-2-4-6(5)10;1-2;;/h1-4,10H,(H,8,9);1H2,2H3;;/q;;2*+1/p-2

InChI 密鑰

RTKIYNMVFMVABJ-UHFFFAOYSA-L

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一般說明

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

應用

Thimerosal EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

生化/生理作用

硫柳汞是一种巯基(硫醇)氧化剂,能抑制多种巯基依赖性酶和蛋白质,如PI3激酶依赖性蛋氨酸合成酶、谷氨酸转运受体和Na++K+依赖性ATP酶。

包裝

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

其他說明

Sales restrictions may apply.

免責聲明

As part of the corporation global plan to support the Minamata Convention in eliminating mercury-containing compounds, as of January 2021 customers will be required to provide an End-Use Declaration. The sales of thimerosal will be restricted for approved applications only, such as preservative in vaccine manufacturing, preservative in eye cosmetics, research use within academia (excluding preservation intent) and as reference material only.

The product is not intended for use as a biocide under global biocide regulations, including but not limited to US EPA′s Federal Insecticide Fungicide and Rodenticide Act , European Biocidal Products Regulation, Canada′s Pest Management Regulatory Agency, Turkey′s Biocidal Products Regulation, Korea′s Consumer Chemical Products and Biocide Safety Management Act (K-BPR) and others.
For U.S. Customers: Contains mercury; Do not place in trash - dispose according to local, state, or federal laws.

訊號詞

Danger

危險分類

Acute Tox. 1 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT RE 2 Oral

標靶器官

Kidney

儲存類別代碼

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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分析證明 (COA)

Lot/Batch Number

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存取文件庫

Global justice and the proposed ban on thimerosal-containing vaccines.
Katherine King et al.
Pediatrics, 131(1), 154-156 (2012-12-19)
Janet K Kern et al.
International journal of environmental research and public health, 10(8), 3771-3800 (2013-08-24)
Autism spectrum disorder (ASD) is a neurological disorder in which a significant number of the children experience a developmental regression characterized by a loss of previously acquired skills and abilities. Typically reported are losses of verbal, nonverbal, and social abilities.
José G Dórea
Clinica chimica acta; international journal of clinical chemistry, 411(21-22), 1580-1586 (2010-07-20)
To compare epidemiological studies dealing with neurological issues (compatible with Hg toxicity) linked to exposing newborns and infants to intramuscular doses of preservative-Hg resulting from vaccination with thimerosal-containing vaccines (TCV). Major databases were searched for studies that addressed neurodevelopment outcomes
L K Ball et al.
Pediatrics, 107(5), 1147-1154 (2001-05-23)
On July 7, 1999, the American Academy of Pediatrics and the US Public Health Service issued a joint statement calling for removal of thimerosal, a mercury-containing preservative, from vaccines. This action was prompted in part by a risk assessment from
José G Dórea
Neurochemical research, 36(6), 927-938 (2011-02-26)
There is a need to interpret neurotoxic studies to help deal with uncertainties surrounding pregnant mothers, newborns and young children who must receive repeated doses of Thimerosal-containing vaccines (TCVs). This review integrates information derived from emerging experimental studies (in vitro

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