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Key Documents

SMB00947

Sigma-Aldrich

N-Desethyl amodiaquine dihydrochloride

≥95%

同義詞:

Monodesethylamodiaquine dihydrochloride

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About This Item

經驗公式(希爾表示法):
C18H18ClN3O · 2HCl
CAS號碼:
分子量::
400.73
分類程式碼代碼:
41116107
NACRES:
NA.77

生物源

synthetic

品質等級

化驗

≥95%

形狀

solid

分子量

400.73 g/mol

技術

HPLC: suitable

顏色

yellow to dark yellow

溶解度

DMSO: soluble
methanol: soluble
water: soluble

儲存溫度

2-8°C

應用

Amodiaquine (AQ) is currently used in combination with Artesunate (AS) as first-line treatment for some cases of falciparum malaria (UM) in many countries. AQ is metabolized by hepatic cytochrome P450 2C8 (CYP2C8) to Desethylamodiaquine (DAQ; DEAQ; NADQ; Ndes-amo), which is subsequently eliminated via extra-hepatic biotransformation by CYP1A1 and CYP1B1. DEAQ is responsible for the pharmacological activity of AQ (both therapeutic and toxicity) due to its long elimination half-life.
Metabolomics research

其他說明

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儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Journal of medical virology, 91(7), 1182-1190 (2019-02-26)
Studies aimed at repurposing existing drugs revealed that some antimalarial compounds possess anti-Zika virus (anti-ZIKV) activity. Here, we further tested 14 additional antimalarial drugs and their metabolites or analogs for anti-ZIKV activity using a phenotypic screening approach. We identified four

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